1955 CE
#1207
The disulphide bonds of insulin.
Sanger sequenced the amino acids of insulin, the first of any protein. His work “revealed that a protein has a definite constant, genetically determined sequence—and yet a sequence with no general rule for…
1977 CE
#6883
DNA sequencing with chain-terminating inhibitors.
Sanger and colleagues developed methods for rapid sequencing of long sections of DNA molecules. Sanger’s method, and that developed by Gilbert and Maxam, made it possible to read the nucleotide sequence for enti…
1977 CE
#6884
The nucleotide sequence of bacteriophage phi-X174.
Sanger and colleagues sequenced the first whole DNA genome—that of bacteriophage phi-X174 (5375 bases)
1980 CE
#6893
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.
Sanger and colleagues developed the random shotgun method to prepare templates for DNA sequencing. With A. R. Coulson, B. G. Barrell, A. J. H. Smith & B. A. Roe.
1982 CE
#6885
Nucleotide sequence of bacteriophage lambda.
Sanger and colleagues sequenced the entire genome of bacteriophage lambda using a random shotgun technique. This was the first whole genome shotgun (WGS) sequence.