The complete amino acid sequence of the tryptophan synthesase a protein (α Subunit) and its colinear relationship with the genetic map of the gene.

Yanofsky showed that changes in DNA sequence can produce changes in protein sequence at corresponding positions. His work is considered the best evidence in favor of the one gene-one enzyme hypothesis. Order of authorship in the original publication: Yanofsky, Drapeau, Guest, Carlton. Digital facsimile from PubMedCentral at this link.