Cautions against the immoderate use of snuff. Founded on the known qualities of the tobacco Plant; and the effects it must produce when this way taken Into the body: And by instances of persons who have perished miserably of diseases, occasioned, or rendered incurable by its use,

First clinical report (pp. 30-31) of an association between tobacco and cancer, in this case “polypusses” of the nose caused by taking snuff. Hill was a distinguished botanist and apothecary, although regarded by some as a quack. See D.E. Redmond, Jr., Tobacco and cancer: the first clinical report. New Eng. J. Med., (1970), 282, 18-23.

Digital facsimile of the second edition, also published in 1761, from the Internet Archive at this link.