Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP.

Discovery of ubiquitin-mediated protein degradation. The paper is available at  doi:10.1073/pnas.76.7.3107,PMC 383772, PMID 290989.

See also Hershko, A.; Ciechanover, A.; Heller, H.; Haas, A.L.; Rose, I.A. (1980), "Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis", Proc. Natl. Acad. Sci. USA 77 (4): 1783-1786. doi:10.1073/pnas.77.4.1783,  PMC 348591, PMID 6990414.

In 2004 Ciechanover, Hershko and Rose shared the Nobel Prize in Chemistry "for the discovery of ubiquitin-mediated protein degradation."