Facets

1966 CE

#14064

"Fertile" intestine nuclei.

Gurdon and Uehlinger replaced the cell nucleus of frog ova with frog intestinal nuclei to generate tadpoles, some of which became fertile adult male and female frogs. In 2012 the Nobel Prize in Physiology or Medicine …

1708 CE

#11673

An account of animal secretion, the quantity of blood in the humane body, and muscular motion.

Keill applied measurement and mathematics in his researches, claiming the "first calculations of the absolute velocity at which blood travels through the aorta and smaller vessels; he also recognized that the blood's …

2018 CE

#14146

Cloning of Macaque monkeys by somatic cell nuclear transfer.

The authors at the Chinese Academy of Sciences in Shanghai reported the first cloning of a non-human primate. Full text available from cell.com at this link. Order of authorship in the original publication: Liu, Cai..…

1973 CE

#2700.4

Computerized transverse axial scanning (tomography).

Hounsfield invented computer-assisted tomography (CAT), or computed tomography (CT). In 1979 Hounsfield shared the Nobel Prize in Physiology or Medicine with Allen M. Cormack "for the development of computer assisted …

1965 CE

#8834

Computers in biomedical research. Edited by Ralph W. Stacy and Bruce Waxman. 2 vols.

Section A, Chapter 2: "New mathematical methods in the life sciences" by George B. Dantzig. Section D, Chapter 12: "The application of computers to electroencephalography" by Mary A. B. Brazier. Section E, Chapter 13:…

1892 CE

#641

Das Gesetz der Transformation der Knochen.

“Wolff’s law” stated that every change in form and function of a bone, or in its function alone, is followed by certain definite changes in its internal architecture and equally definite secondary al…

1680 CE–1681 CE

#3669.3

De motu animalium. 2 pts.

Borelli originated the neurogenic theory of the heart’s action and first suggested that the circulation resembled a simple hydraulic system. He was the first to insist that the heart beat was a simple muscular c…

1683 CE

#4162

De urinis et pulsibus de missione sanguinis de febribus de morbis capitis, et pectoris.

Bellini began to develop his hydraulic iatromechanics in this work, in which he considered the blood as a physical fluid with simple mechanical and mathematicizable properties. He realized the value of the urine as an…

1895 CE–1904 CE

#645

Der Gang des Menschen. 1-6 Abt. (All published.)

Classic study of the human gait. The authors calculated the external and internal forces involved in walking and described the kinematics and kinetics of the movement. Because of Braune's death in 1892 he could only c…

1891 CE

#637

Die Bewegungen des Kniegelenkes.

Investigation of the mechanics of motion of the knee joint on mathematical lines. See also No. 645.

1899 CE

#12286

Die Grundform des arteriellen Pulses.

"The First Mathematical Description of the Pressure-Volume Diagram "Not until 60 years after 1899 Otto Frank's mathematical formulation of the volume-pressure diagram and his concept of the mechanism of the cardiac wo…

1738 CE

#11713

Dissertatio de structura et motu musculari.

This was the text of the first Croonian Lecture at the Royal Society. In it Stuart promoted a strictly hydraulic iatromechanism as a theory of muscular motion. This work was translated into English in 1739. Digital fa…

1667 CE

#577

Elementorum myologiae specimen.

In this work Stensen, in collaboration with the mathematician Vincenzio Viviani (1622-1703), a pupil of Galileo, developed a geometrical description of muscular contraction, and attempted to show theoretically that mu…

1998 CE

#13286

Embryonic stem cell lines derived from human blastocysts.

Thomson and collaborators first isolated embryonic stem cells from human blastocysts. Order of authorship in original publication: Thomson, Itskovitz-Eldor, Shapiro et al. Available online from science.sciencemag.org …

1981 CE

#13285

Establishment in culture of pluripotential cells from mouse embryos.

Evans and Kauffman were the first to identify, isolate and successfully culture embryonic stem cells using mouse blastocysts. This discovery opened the doors to the creation of “murine genetic models” -- m…

1968 CE

#11551

Hydrodynamics and hydraulics by Daniel Bernoulli and Johann Bernoulli. Translated by Thomas Carmody and Helmut Kobus.

Daniel Bernoulli’s Hydrodynamica, published in 1738, marks the first appearance of many topics central to modern science - from the kinetic theory of gases to the principles of jet propulsion. John Bernoulli&rsq…

2006 CE

#13287

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Takahashi and Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. This they a…

1891 CE

#638

Le travail musculaire et l’énergie qu’il représente.

Important studies on thermodynamics of muscular work.

1836 CE

#604

Mechanik der menschlichen Gehwerkzeuge. 1 vol. and atlas.

A pioneering study of the physiology and biomechanics of motion and locomotion. The atlas contains four illustrations that were printed directly from actual bones embedded in plaster of Paris. This is one of the only …

1963 CE

#8149

Representation of a Function by its Line Integrals, with Some Radiological Applications.

Cormack showed that changes in tissue density could be computed from x-ray data. Because of limitations in computing power no machine was constructed during the 1960s. Cormack's papers generated little interest until …

1987 CE

#13931

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

In 2007 Capecchi shared the 2007 Nobel Prize in Physiology or Medicine with Martin J. Evans and Oliver Smithies "for their discoveries of principles for introducing specific gene modifications in mice by the use of em…

1987 CE

#13940

Targeted correction of a mutant HPRT gene in mouse embryonic stem cells.

Smithies discovered, simultaneously with Mario Capecchi and Martin Evans, the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previ…

1833 CE

#411.1

The hand: Its mechanism and vital endowments as evincing design.

Classic work on the anatomy, physiology, bio-mechanics, comparative anatomy, and adaptive importance of the hand. Issued as a volume in a series entitled the "Bridgewater Treatises." The first edition has 288pp. An en…

1997 CE

#7457

Viable offspring derived from fetal and adult mammalian cells.

Cloning of the lamb Dolly, the first mammal to be cloned from an adult cell. Her birth established that the nuclei of at least some adult cells can be used to produce sheep or other animals that are genetically identi…