Facets

1840 CE

#6921

Der Chemismus in der thierischen Organisation.

Hünefeld accidentally observed the first protein crystals— those of hemoglobin—in partically dried samples of mammalian blood blood pressed between glass plates. On page 160 Hünefeld noted that h…

2021 CE

#13478

CRISPR-Cas9 gene editing for sickle cell disease and ß-thalassemia.

First application of CRISPR gene editing in the successful cure of diseases. Order of authorship in the original publication: Frangoul, Altshuler, Cappellini. (Thanks to Juan Weiss for this reference and its interpret…

1938 CE

#6915

Das Gleichgewicht zwischen Hämoglobin and Sauerstoff.

Haurowitz discovered that crystalline deoxyhemoglobin changes in shape and color on reaction with oxygen, suggesting that it is a molecular lung.

1909 CE

#12426

Der Lymphozyt als gemeinsame Stammzelle der verschiedenen Blutelemente in der embryonalen Entwicklung und im postfetalen Leben der Säugetiere.

Maximow developed and introduced a unitarian theory of hematopoiesis, a theory upon which the modern concept of blood cells' origin and differentiation is based. He introduced the term "stem cell." Translated into Eng…

2001 CE

#10335

Dying in the City of the Blues: Sickle cell anemia and the politics of race and health.

"Set in Memphis, home of one of the nation's first sickle cell clinics, Dying in the City of the Blues reveals how the recognition, treatment, social understanding, and symbolism of the disease evolved in the twentiet…

1985 CE

#10785

Enzymatic amplication of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Polymerase chain reaction first published. With Randall K. Saiki, Stephen Scharf, Fred Faloona et al. Order of authorship in the original paper was Saiki, Scharf, Faloona, Mullis.... In 1993 the Nobel Prize in Chemist…

1968 CE

#6916

Molecular pathology of human haemoglobin.

Perutz opened up "the field of 'molecular pathology,' relating a structural abnormality to a disease" (Aaron Klug, "Max Perutz 1914-2002," Science 295 ([2002] 2383). Specifically Perutz showed that hemoglobin molecule…

2014 CE

#11745

Reading vampire gothic through blood: Bloodlines.

1941 CE

#12823

Report of the Blood Transfusion Association concerning the Project for Supplying Blood Plasma to England, which has been carried on jointly with the American Red Cross from August, 1940, to January, 1941. Narrative account of work and medical report.

Drew discovered the method for long-term storage of blood plasma, and organized America's first large-scale blood bank. Drew's thesis for his medical degree at Columbia was entitled "Banked Blood: A Study in Blood Pre…

1949 CE

#3154.1

Sickle cell anemia, a molecular disease.

First recognition, by Pauling and colleagues, of a structural hemoglobin variant, and the beginning of the molecular approach to disease.

1909 CE

#6845

The differentiation and specificity of corresponding proteins and other vital substances in relation to biological classification and organic evolution: The crystallography of hemoglobins.

This massive work with 100 plates including 600 images, was the first large-scale investigation of species differences at the molecular level. Digital facsimile from the Internet Archive at this link.