GILMAN, Alfred Goodman (1941 – 2015)
1941 – 2015
2 entries in the GMN corpus.
Image source NIH historic image · profiles.nlm.nih.gov · Public domain
1977 CE
#14143
Resolution of some components of adenylate cyclase necessary for catalytic activity.
Goodman shared the 1994 Nobel Prize in Physiology or Medicine with Martin Rodbell "for their discovery of G-proteins and the role of these proteins in signal transduction in cells." In this paper Goodman and Ross show…
1978 CE
#14144
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.
Gilman and colleagues showed that G proteins are in the cell membrane and are stimulated once a ligand (adrenaline) binds the adrenergic receptor. This system can then activate adenyl cyclase to form cyclic AMP. Digit…