MAGENDIE, François (1783 – 1855)

1809 CE

#9578

Examen de l'action de quelques végétaux sur la moelle épinière. Lu a l'Institut, le vingt-quatre avril 1809.

In 1809 Magendie presented to the Académie des Sciences and to the Société Philomatique the results of his first experimental work, which he carried out in collaboration with the botanist and phys…

1813 CE

#985.1

Mémoire sur l’usage de l’epiglotte dans la déglutition …

Magendie showed that the epiglottis is not necessary for swallowing, which disproved the accepted doctrine that the epiglottis was necessary to cover the glottis to prevent food from entering the trachea.

1813 CE

#985

Mémoire sur le vomissement.

Physiologists still consult Magendie’s classic description of the physiology of deglutition and vomiting. Magendie proved, against the current theory of Haller, that the stomach was passive rather than active in…

1816 CE–1817 CE

#1041.1

Précis élémentaire de physiologie. 2 vols.

The first modern physiology textbook, in which doctrine gave way to simple, precise descriptions of experimental facts. Vol. 2 contains Magendie’s classic demonstration of the importance of nitrogenous food, or …

1817 CE

#1843

Mémoire sur l’émétine, et sur les trois espèces d’ipecacuanha.

Isolation of emetine. It was not until a century later that Vedder demonstrated its value in the treatment of amoebiasis. Also during 1817 Magendie and Pelletier published "Recherches chimiques et physiologiques sur l…

1821 CE

#1846

Formulaire pour la préparation et l’emploi de plusieurs nouveaux médicamens, tels que la noix vomique, la morphine, etc.

Magendie was the pioneer of experimental physiology in France. His Formulaire introduced into medical practice several of the newly discovered alkaloids, notably morphine, veratrine, brucine, piperine, emetine, as wel…

1821 CE

#598

Mémoires sur le mécanisme de l’absorption chez les animaux à sang rouge et chaud.

Magendie, the pioneer of experimental physiology in France, demonstrated the absorption of fluids and semisolids to be a function of the blood-vessels, as well as of the lymphatics. He was the founder, in 1821, of the…

1822 CE

#1256.1

Expériences sur les fonctions des racines des nerfs qui naissent de la moelle épinière.

Further experiments, including, most probably, “the first use of strychnine as part of a study of the localization of function in the nervous system as well as being a very early example of the rational use of a…

1822 CE

#1256

Expériences sur les fonctions des racines des nerfs rachidiens.

Magendie definitely discovered that the anterior root is motor and that the dorsal root is sensory, although Romberg, Flourens, Sherrington, and others credited the discovery to Charles Bell. In this paper Magendie an…

1825 CE

#1392

Mémoire sur un liquide qui se trouve dans le crâne et le canal vertebral de l’homme et des animaux mammifères.

First clear description of the cerebrospinal fluid.

1836 CE–1838 CE

#2217

Leçons sur les phénomènes physiques de la vie. 4 vols.

Magendie, pioneer experimental physiologist, regarded pathology as only a modification of physiology, “medicine the physiology of the sick man”. By him clinical medicine was reconstructed on physiological …

1839 CE

#2585

Lectures on the blood, and on the changes which it undergoes during disease: Delivered at the College of France in 1837-8.

Pp. 244-49: Magendie showed that secondary or subsequent injections of egg/albumin caused death in rabbits who had tolerated an initial injection. This was the first experiment in anaphylaxis, though Jenner in 1798 ha…

1842 CE

#1397

Recherches physiologiques et cliniques sur le liquide céphalo-rachidien ou cérébro-spinal. 1 vol. and atlas.

“Foramen of Magendie” described.

1844 CE

#11666

Voyage scientifique à Naples avec M. Magendie en 1843.

Digital facsimile from wellcomecollection.org at this link.

1974 CE

#1588.14

The way in and the way out. François Magendie, Charles Bell and the roots of the spinal nerves. With a facsimile of Charles Bell’s annotated copy of his Idea of a new anatomy of the brain. Edited by Paul Cranefield.

An annotated bibliography of the literature documenting the history of this controversy together with reproductions of the texts of the crucial papers. See Nos. 1254-1259.