LEDERBERG, Joshua (1925 – 2008)

1946 CE

#255.4

Gene recombination in Escherichia coli.

Discovery of sexual processes in the reproduction of bacteria. In 1958 Lederberg shared the Nobel Prize in Physiology or Medicine with Tatum and Beadle (No. 254.3) "for his discoveries concerning genetic recombination…

1952 CE

#256.1

Genetic exchange in Salmonella.

Description of a new mechanism (“transduction”) for the transfer of genetic characters from one bacterial strain to another.

1952 CE

#13970

Genetic exchange in salmonella.

Working as a graduate student with Lederberg, Zinder discovered that a bacteriophage can carry genes from one bacterium to another. Initial experiments were carried out using Salmonella. Zinder and Lederberg named thi…

1952 CE

#9719

Replica plating and indirect selection of bacterial mutants.

Demonstration of the mutational basis of antibiotic resistance. Digital facsimile from PubMedCentral at this link.

1964 CE

#8174

HPP-64-1 DENDRAL-64-A system for computer construction, enumeration and notation of organic molecules as three structures and cyclic graphs. Interim report to the National Aeronautics and Space Administration, December 15, (1964).

DENDRAL is considered the first expert system because it automated the decision-making process and problem-solving behavior of organic chemists. The project consisted of research on two main programs, Heuristic Dendra…

1980 CE

#8175

Applications of artificial intelligence for organic chemistry: The Dendral project.

1994 CE

#10195

A history of gene transfer and therapy by Jon A. Wolff and Joshua Lederberg in: Wolff, Jon A. (ed.) Gene therapeutics: Methods and applications of direct gene transfer, pp.3-25.

Valuable for its detailed, but highly compressed discussion of the earliest history of these subjects, co-authored by Lederberg, who played a significant role during that period.