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CHANG, Annie C.Y. (1936 – )

1936 –

3 entries in the GMN corpus.

1973 CE

#257.5

Construction of biologically functional bacterial plasmids in vitro.

Cohen, Boyer and associates developed the first practical method for cloning genes, by the formation of recombinant plasmids which can be used to infect plasmid-free bacteria. The authors demonstrated that if DNA is f…

1974 CE

#10047

Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.

Creation of the first transgenic organism: expression of Staphylococcus aureus genes in Escherichia coli. Digital facsimile from pnas.org at this link.

1974 CE

#10963

Genome construction between bacterial species in vitro: Replication and expression of staphylococcus plasmid genes in Escherichia coli.

Confirmation of the success of methods outlined in No. 257.5. Abstract: "Genes carried by EcoRI endonuclease-generated fragments of Staphylococcus plasmid DNA have been covalently joined to the E. coli antibiotic-resi…