George A Sacher, Life table modification and life prolongation. IN: Handbook of the biology of aging, edited by Caleb E. Finch and Leonard Hayflick, pp. 582–638.
Publication Details
New York: Van Nostrand Reinhold, 1970 CE.
"The building of a connection between the Gompertz equation and the biology of ageing owes much to the work of biophysicist George Sacher [10] of the Argonne National Laboratory, whose introduction to ageing stemmed from the growing recognition during the 1950s that irradiation would shorten length of life [11]. The same recognition led physicist Leo Szilard [12] to propose the somatic mutation theory of ageing and prompted a range of studies on the effects of radiation on ageing both in animal models such as Drosophila (e.g. [13]) and also in human survivors of atomic bomb irradiation [14].
Sacher [10] used the Gompertz model to compare the patterns of increase in age-specific mortality rates across different species. By plotting age-specific mortality on a logarithmic scale against age (figure 1), he showed that a linear increase was generally observed, in accordance with the logarithmic version of equation (1.1), i.e.
"Thomas B. L. Kirkwood, Decipherng death: a commentary on Gompertz (1825) 'On the nature of the function express of the law of human mortality and on a new mode of determining the value of life contingencies"). (http://rstb.royalsocietypublishing.org/content/370/1666/20140379, accessed 01-2017
Thematic Classifications
| Catalog Metadata | Reference Information |
|---|---|
| Entry Number | #8380 |
| Permanent Link | https://hom-sveltekit.fly.dev/entry/10557 |
| Author Bio Link | academic.oup.com ↗ |
| External URL | life-table-modification-and-life-prolongation-in-handbook-of-the-biology-of-aging-edited-by-c-e-finch-and-leonard-hayflick-pp-582638- |
Geographic Context
Publication place: New York