De morbis venereis libri sex.

A comprehensive book on the subject, including a careful review of the existing literature. Astruc stated that syphilis first appeared in Europe in 1493. The book was translated into English in 1737. Digital facsimile of the 1736 edition from wellcomecollection.org at this link.

In 1740 Astruc issued the much-enlarged second edition expanded to two volumes. At the end of vol. 1, paginated in Roman numerals, he published Dissertatio I. De origine, appelatione, natura & curatione morborum venerorum inter Sinas, reproducing various Chinese characters with their explanations. This was probably the first Chinese treatise on venereal disease published in Europe. Digital facsimile of the second edition from Google Books at this link.