Di Pedacio Dioscoride Anazarbeo Libri cinque della historia, et materia medicinale tradotti in lingua volgare italiana da M. Pietro Andrea Matthiolo Sanese Medico, con amplissimi discorsi, et comenti, et dottissime annotationi, et censure del medesimo interprete.

Mattioli's translation and commentary on Dioscorides provided much new botanical information. As Mattioli continued to expand the commentary, adding new botanical and pharmacological information, through editions in Latin, the images of plants that the work contained also increased both in number and in size and quality, the largest and finest images appearing in the edition of Venice, 1565. Digital facsimile of the 1565 edition from the Biodiversity Heritage Library at this link.