Facets

1840 CE

#6921

Der Chemismus in der thierischen Organisation.

Hünefeld accidentally observed the first protein crystals— those of hemoglobin—in partically dried samples of mammalian blood blood pressed between glass plates. On page 160 Hünefeld noted that h…

1944 CE

#751.2

Chemical, clinical, and immunological studies on the products of human plasma fractionation. I. The characterization of the protein fractions of human plasma.

Cohn invented fractionation of plasma proteins, also called blood fractionation. (Order of authorship in the original publication: Cohn, Oncley, Strong, Hughes, Armstrong.) Digital facsimile from PubMedCentral at this…

1825 CE

#14177

Commentatio de vera materiae sanguini purpureum colorem impertientis natura.

Engelhart’s dissertation, presented before the medical faculty at the University of Göttingen, contains the first determination of the molecular mass of a protein (hemoglobin). Engelhart proved that the rat…

1908 CE

#9645

Concerning the relationship between the strength of acids and their capacity to preserve neutrality.

Henderson-Hasselbalch equation for the determination of pH concentration in the blood. See Hasselbalch's paper. Digital facsimile of Henderson's paper from the American Journal of Physiology at this link. Henderson's …

1938 CE

#6915

Das Gleichgewicht zwischen Hämoglobin and Sauerstoff.

Haurowitz discovered that crystalline deoxyhemoglobin changes in shape and color on reaction with oxygen, suggesting that it is a molecular lung.

1917 CE

#742

Die Berechnung der Wasserstoffzahl des Blutes aus der freien und gebundenen Kohlensäure desselben, und die Sauerstoffbindung des Blutes als Funktion der Wasserstoffzahl.

Henderson-Hasselbalch equation for the determination of pH concentration in the blood. English translation in No. 1588.16. For Henderson's papers see No. 9645.

1876 CE

#696

Die quantitative Spectralanalyse in ihrer Anwendung auf Physiologie, Physik, Chemie und Technologie.

Vierordt’s spectral analyses of hemoglobin, bile and urine were of great value. He studied the variations in the spectrum of oxyhemoglobin produced by different dilutions of this substance and was thus able to e…

1866 CE

#3119

Ein Fall von Anaemia splenica bei einem Kinde

First reported case of (infantile) splenic anemia.

1985 CE

#10785

Enzymatic amplication of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Polymerase chain reaction first published. With Randall K. Saiki, Stephen Scharf, Fred Faloona et al. Order of authorship in the original paper was Saiki, Scharf, Faloona, Mullis.... In 1993 the Nobel Prize in Chemist…

1938 CE

#3787.1

Hemolysins as the cause of clinical and experimental hemolytic anemias.

Acquired hemolytic anemia was the first condition to be recognized as an auto-immune disease.

1907 CE

#3783

Ictères hémolytiques non congénitaux avec anémie.

“Widal-Abrami disease” (Hayem-Widal disease), acquired hemolytic anemia. (See also No. 3777.)

1894 CE

#3774

La splenomegalia con cirrosi del fegato

“Banti’s syndrome”, Splenomegalic anemia. Reprinted with translation in Med. Classics, 1937, 1, 901-27. (For his earlier work on the subject, see No. 3126.)

1684 CE

#861

Memoirs for the natural history of humane blood, especially the spirit of that liquor.

The first analysis of blood, Boyle’s Memoirs may be considered the first scientific study in physiological chemistry, exhibiting methods which have become universally adopted. This is Boyle’s most importan…

1906 CE

#730.1

Note upon the presence of amino-acids in the blood and lymph as determined by the ß naphthalinsulphochloride reaction.

Demonstration of the presence of amino-acids in the blood.

1896 CE

#647

On the absorption of fluids from the connective tissue spaces.

Starling discovered the functional significance of the serum proteins.

1924 CE

#747

Studies in nuclein metabolism. II. The isolation of a nucleotide from human blood.

Jackson demonstrated the existence of pentose nucleotides in normal blood.

1898 CE

#3777

Sur une variété particulière d’ictère chronique splénomégalique.

“Hayem–Widal disease” –acquired hemolytic anemia (see also No. 3783).

1891 CE

#717

The behaviour of saccharine matter in the blood.

Destruction of sugar in the blood.

1924 CE

#963.1

The determination of gases in blood and other solutions by vacuum extraction and manometric measurement.

Method for the manometric analysis of gases in blood and other solutions.

1904 CE

#726

Ueber einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt.

Bohr, Hasselbalch, and Krogh showed, in the experimental animal, that the affinity of blood for oxygen depends upon carbon dioxide pressure. This became known as the Bohr effect, though the discovery may have been mad…