2005 CE
#13622
Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.
Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…
2017 CE
#14201
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.
Prior to their development of the mRNA vaccine for Covid-19, Karikó and Weissman (Nobel Prize 2023) and colleagues used a novel mRNA vaccine, with base modifications created in their laboratory, to generate a p…