MEDAWAR, Sir Peter Brian (1915 – 1987)

1943 CE

#2578.4

The fate of skin homografts in man.

Gibson and Medawar placed the laws of transplantation on a firm scientific basis. A later paper by Medawar (J. Anat. [Lond.], 1944, 78, 176- 99) demonstrated that the mechanism of rejection of transplanted tissues is …

1951 CE

#13595

The technique of free skin grafting in mammals.

This "paper facilitated the later discovery of `actively acquired tolerance' and the definition of the principal laws of transplantation tolerance. Thus, it was in a series of classic experiments (stemming from this J…

1953 CE

#2578.11

‘Actively acquired tolerance’ of foreign cells.

Proof of Burnet and Fenner’s theory of immunity. For their discovery of acquired immunological tolerance Medawar and Burnet (No. 2578.7) shared the Nobel Prize in 1960.

1954 CE

#2578.12

Quantitative studies on tissue transplantation immunity. I. The survival times of skin homografts exchanged between members of different inbred strains of mice. II. The origin, strength and duration of actively and adoptively acquired immunity.

Experimental production of immunological tolerance by Billingham and colleagues.Paper II distinguished adoptive from passive immunization. E. M. Sparrow was a co-author of paper I.

1958 CE

#2578.24

The homograft reaction.

Medawar showed grafting to be unsuccessful when donor and recipient animals came from the same litter, unless the two are genetically identical – another instance of the delayed hypersensitivity reaction.