Facets

1878 CE

#2536

Untersuchungen über die Aetiologie der Wundinfectionskrankheiten.

Koch’s epochal work on the etiology of traumatic infectious disease established his reputation. He inoculated animals with material from various sources and produced six types of infection, each due to microorga…

1860 CE

#534.62

Untersuchungen über die Entstehung der Missbildungen Zunächst in den Eiem der Vögel.

The first monograph on experimental teratology.

1857 CE

#13248

Untersuchungen uber die Entwickelung des Schädelgrundes im gesunden und krankhaften Zustande und über Einfluss derselben auf Schädelform, Gesichtsbildung und Gehirnbau.

In his Investigations on the development of the base of the skull in healthy and diseased conditions, and on the influence of the same upon skull form, facial structure and brain formation Virchow laid the foundation …

1857 CE

#3935

Untersuchungen über die Honigharnruhr.

Petters discovered acetone in diabetic urine.

1897 CE

#1475

Untersuchungen über die Sinnesfunctionen der menschlichen Haut. I. Druckempfindung und Schmerz.

In his investigations on cutaneous sensibility Frey introduced his method of testing the sensitiveness of pressure points by means of bristles mounted in a handle.

1859 CE

#3819

Untersuchungen über die Zuckerbildung in der Leber und den Einfluss des Nervensystems auf die Erzeugung des Diabetes.

Schiff’s reports on his experimental thyroidectomies, which were attended with fatal results. Subsequently (Arch. exp. Path. Pharmak., 1884, 18, 25) he showed that intra-abdominal transplantation of the gland wo…

1913 CE

#2640

Untersuchungen über eine Nematode (Spiroptera sp. n.) und deren Fähigkeit papillomatöse und carcinomatose Geschwulstbildungen im Magen der Ratte hervorzurufen.

Fibiger demonstrated that the roundworm, which he called Spiroptera carcinoma (but is correctly named Gongylonema neoplasticum), could cause stomach cancer (squamous cell carcinoma) in rats and mice. His experimental …

1885 CE

#10383

Untersuchungen über staubinhalation und staubmetastase.

On the effects of dust inhalation. Digital facsimile from the Internet Archive at this link.

1905 CE

#2592

Ursache und Behandlung des Heufiebers.

Dunbar studied the relationship of pollen to hay fever, separated the active substances responsible for producing the condition, and introduced a specific therapy.

1932 CE

#5465

Vaccination against yellow fever with immune serum and virus fixed for mice.

These workers devised an immune serum for prophylactic inoculation against yellow fever. With S. F. Kitchen and W. D. M. Lloyd.

1899 CE

#5429

Vaccination, its natural history and pathology.

Milroy Lectures, Royal College of Physicians, 1898. Copeman’s bacteriological studies permanently determined the validity of vaccination as a preventive of smallpox.

1969 CE–1972 CE

#6841

Vaccine against viral hepatitis and process. Serial No. 864,788 filed 10 /8 /[19]69. Patent 3636191 issued 1/ 18/ [19]72.

First description of the hepatitis B vaccine, the first cancer vaccine, US patent 3636191A. Millman and Blumberg discovered that the blood of individuals carrying the hepatitis B virus contained particles of the outsi…

2015 CE

#12441

Vaccine nation: America's changing relationship with immunization.

2012 CE

#12350

Vaccine: The debate in modern America.

2010 CE

#8099

Vaccines: A biography. Edited by Andrew W. Artenstein.

1924 CE

#2602

Vascular reactions of the skin to injury. II. The liberation of a histamine-like substance in injured skin; the underlying cause of factitious urticaria and of wheals produced by burning; and observations upon the nervous control of certain skin reactions.

Lewis postulated that a histamine-like substance (“H-substance”) was responsible for the anaphylaxis symptom-complex. See also The blood-vessels of the human skin and their responses, 1927 (No. 797).

1920 CE

#3796

Verjüngung durch experimentelle Neubelebung der alternden Pubertätsdrüse

Steinach rejuvenation operation, ligation of the vas deferens, later discredited.

1845 CE

#3991

Versuch einer auf pathologische Anatomie gegründeten Eintheilung der Hautkrankheiten.

Hebra’s classification of skin diseases was based upon their pathological anatomy.

1891 CE

#4106

Vier Fälle von Elephantiasis congenita hereditaria.

First description of hereditary oedema of the legs, generally known as “Milroy’s disease” or as “Meige’s disease” (No. 4129).

1970 CE

#2660.22

Viral RNA-dependent DNA polymerase: RNA-dependent DNA polymerase in virions of RNA tumour viruses.

In 1970 Baltimore and Temin discovered that certain viruses that have their genes in the form of RNA can copy the RNA "backward" into DNA in infected cells. The enyzme, reverse transcriptase, enables the manufacture o…

1957 CE

#2578.22

Virus interference. I. The interferon.

Discovery of interferon type I, a protein that interferes with viral replication. "While working together at the NIMR, Lindenmann and Isaacs noticed that if they killed viruses using heat and applied the dead viruses …

1964 CE

#2660.18

Virus particles in cultured lymphoblasts from Burkitt’s lymphoma.

Order of authorship in the original publication: Epstein, Achong, Barr. Presence of herpes-like virus particles in Burkitt’s tumor cells reported. The Epstein-Barr virus was the first human cancer-causing virus …

1960 CE

#2660.13

Virus-cell interaction with a tumour-producing virus.

Polyomavirus (papovavirus) shown to be capable of transforming cells in culture. Full text from PubMedCentral at this link.

1792 CE

#6358

Von Menschen ohne Haare und Zähne.

Hereditary ectodermal dysplasia first described. Digital facsimile from Google Books at this link.

1879 CE

#4071

Warty growths.

Original description of angiokeratoma (“Mibelli’s disease” – so named from the latter’s description of it in 1891; see No. 4105).

1845 CE

#3062

Weisses Blut.

Only six weeks after Bennett, Virchow independently published a report on the necropsy of a case of leukemia. He gave the condition its present name. For translation, see Major, Classic descriptions of disease, 3rd. e…

1890 CE

#2332

Weitere Mittheilungen über ein Heilmittel gegen Tuberkulose.

In 1890, Koch announced the discovery of tuberculin, a substance derived from tubercle bacilli, which he thought was capable of arresting bacterial development in-vitro and in animals. This news gave rise to tremendou…

1910 CE

#3190

Weitere Untersuchungen über Pneumokokken-Heilsera. III. Mitteilung. Über Vorkommen und Bedeutung atypischer Varietäten des Pneumokokkus.

New antipneumococcus serum.

1922 CE

#6609.1

Wunder, Wundgeburt und Wundergestalt in Einblattdrucken des 15-18. Jahrhunderts.

History of teratology in art from 15th to 18th centuries.

1880 CE

#3473.1

Wyçiecie raka odźwiernika zoladkowego, śmierćw 12 godzinach.

First extirpation of carcinomatous pylorus. Death after 12 hours. German translation in Dtsch. Z. Chir., 1881, 14, 252-60.

1889 CE

#4096.1

Xanthélasma disséminé et symétrique, sans insufficance hépatique.

In 1889 Chauffard gave an important description of pseudoxanthoma elasticum. Further reports on his patient were published by Besnier and Doyon, Darier, and Hallopeau and Laffitte, the last in Ann. Derm. Syph. (Paris)…

1882 CE

#4080

Xeroderma pigmentosum.

Excellent pathological study of this condition (“Kaposi’s disease”), which he first described in Virchow’s Handbuch der speziellen Pathologie und Therapie, 1876, 2, 182.

1913 CE

#3900

Z kazuistyki zmian anatomo-patholigicznych w przysadce mózgowej

Glinski preceded Simmonds in this important description of post-partum necrosis of the anterior pituitary. Abstract in Dtsch med. Wschr., 1913, 39, 473.

1876 CE

#4070.1

Zur Aetiologie der Psoriasis.

“Koebner phenomenon” – appearance at points of injury of any skin lesion that is not an ordinary manifestation or complication of the injury.

1896 CE

#5111

Zur aktiven Immunisierung des Menschen gegen Cholera.

Kolle introduced the killed cholera vaccine.

1899 CE

#6109.1

Zur Casuistik einiger seltenerer Ovarial- und Tuben-Tumoren.

“Brenner tumor” first described; see also No. 6118.

1911 CE

#2638

Zur Diagnose des Karzinoms.

A serum reaction, employed by Freund and Kaminer in 1910 for the diagnosis of cancer.

1847 CE

#2613

Zur Entwickelungsgeschichte des Krebses.

While still a young man Virchow founded the above journal. He wrote a fine paper on cancer and suggested that the exciting cause is local irritation.

1903 CE

#2627

Zur Frage der Beziehungen zwischen Becquerelstrahlen und Hautaffectionen.

Records the first successful employment of radium in the treatment of cancer.

1914 CE

#7759

Zur Frage der Entstehung maligner Tumoren.

Boveri argued that malignancy arises as a consequence of chromosomal abnormalities, and that multiplication is an inherent property of cells. He predicted the existence of tumor suppressor mechanisms and was perhaps t…

1906 CE

#3891

Zur Frage der Operationen an der Hypophyse.

Schloffer’s Operation for acromegaly. He was the first successfully to operate upon a pituitary tumor in man (See No. 3892).

1900 CE

#6114

Zur Frage der Radical operation beim Uteruskrebs.

Wertheim’s radical operation for cancer of the uterus.

1907 CE

#2594.1

Zur Frage der Serum-Ueberempfindlichkeit.

Otto discovered that a state of tolerance developed in animals that survived anaphylactic shock. He induced passive transfer of hypersensitivity.

1995 CE

#12837

Zur Geschichte der Endokrinologie und Reproduktionsmedizin. 256 Biographien und Berichte.

1905 CE

#4140

Zur Kenntnis des Virus des Molluscum contagiosum des Menschen.

Juliusberg showed that the virus of molluscum contagiosum passed a Chamberland filter.

1903 CE

#2112

Zur Kenntniss der Cobragift activirenden Substanzen.

English translation in Ehrlich, Studies in immunity, 1910.

1912 CE

#3845

Zur Kenntniss der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa).

“Hashimoto’s disease”, struma lymphomatosa, lymphoid infiltration of the thyroid.

1874 CE

#3939

Zur Lehre vom diabetes mellitus.

Kussmaul explained diabetic coma as being due to acetonemia. He described the air-hunger (“Kussmaul’s respiration”) present in this condition. Partial English translation in No. 2241.

1903 CE

#2557

Zur Lehre von der Unterscheidung verschiedener Eiweissarten mit Hilfe spezifischer Sera.

Demonstration of organ-specific antigens, in this case in the proteins of the lens of the eye.

1902 CE

#3957

Zur normalen und pathologischen Morphologie der inneren Secretion der Bauchspeicheldrüse. (Die Bedeutung der Langerhans’-schen Inseln.

Sobolew found that ligation of the pancreatic excretory ducts led to atrophy of the acinous tissue, the islets of Langerhans remaining intact.