Facets

1951 CE

#5262.4

2:4-Diaminopyrimidines – a new series of antimalarials.

Preparation and laboratory tests of pyrimethamine. With L. G. Goodwin, G. H. Hutchings, I. M. Rollo, and P. B. Russell.

1951 CE

#5262.5

A 2:4-diamino pyrimidine in the treatment of proguanil-resistant laboratory malarial strains.

Pyrimethamine (daraprim).

1961 CE

#2353.3

A new synthetic compound with antituberculous activity in mice; ethambutol (dextro-2, 2’-(ethylenediimino)-di-l-butanol).

Ethambutol for the treatment of tuberculosis. With C. O. Baughn, R. G. Wilkinson and R. G. Shepherd.

1986 CE

#11106

Administration of 3'-Azido-3'-Deoxythmymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.

Order of authorship in the original publication: Yarchoan, Weinhold, Lyerly. The first antiviral AIDS drug, later named "Retrovir"/ Zidovudine/AZT. (Thanks to Juan Weiss for this reference and its interpretation.)

1764 CE

#9509

An essay on the more common West-India diseases and the remedies which that country itself produces: To which are added some hints on the management, &c. of negroes.

Though the title suggests tropical medicine in general, this work mainly concerns the selection and medical care of slaves. Digital facsimile of the second edition (Edinburgh, 1802) expanded "with practical notes and …

1934 CE

#2415

An experimental study of mapharsen (meta-amino para-hydroxy phenyl arsine oxide) as an antisyphilitic agent.

Introduction of mapharsen.

2021 CE

#14023

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.

The authors showed how a coronavirus specific protease inhibitor designed in the lab, that could be administered by mouth to humans, achieved excellent plasma concentrations and antiviral potency. This drug, marketed …

1663 CE

#1826

Anastasis corticis Peruviae, seu chinae defensio

A defence of the virtues of Jesuit's bark or Peruvian bark (cinchona, chinchona), the most celebrated specific remedy for malaria. It was obtained from the bark of several species of the genus Cinchona, of the Rubiace…

1892 CE

#5243

Azione della chinina sui parasite malarici e sui corrispondente accessi febbrili.

French translation in Arch. ital. Biol., 1892, 17, 456-71.

1907 CE

#5281

Chemotherapeutische Trypanosomen-Studien.

The first account of induced microbial drug resistance. Ehrlich encountered induced drug resistance in microbes while researching arsenical preparations as cures for sleeping sickness and other trypanosome-caused illn…

1964 CE

#5351.6

Chemotherapy of experimental Schistosoma mansoni infections with a nitro-thiazole derivative, CIBA 32, 644-Ba.

Introduction of niridazole (Ambilhar).

1952 CE

#2353

Chemotherapy of human tuberculosis with hydrazine derivatives of isonicotinic acid. (Preliminary report of representative cases.)

Introduction of isoniazid. With I. J. Selikoff and G. G. Omstein. See also Amer. Rev. Tuberc., 1952, 65, 257-442.

1938 CE

#1951

Chemotherapy of pneumococcal and other infections with 2-(p-aminobenzenesulphonamido) pyridine.

Experimental proof of the efficacy of sulfapyridine (M & B 693) in pneumococcal pneumonia.

1946 CE

#2359

Chemotherapy of tuberculosis. Researches during the past 100 years.

1923 CE

#5288

Chimiothérapie des trypanosomiasis.

Introduction of moranyl (“Foumeau 309”).

1947 CE

#1940

Chloromycetin, an antibiotic with chemotherapeutic activity in experimental rickettsial and viral infections.

Introduction of chloramphenicol, used in treatment of typhus.

1946 CE

#5261.1

Chloroquine for treatment of acute attacks of vivax malaria.

Harry Most led the development of chloroquine for use in treating American troops suffering from malaria. At the beginning of the American involvement in the war there were more American casualties from malaria than f…

1956 CE

#2442.2

Clinical trials of diphenyl thiourea compound SU 1906 (Ciba 1509E) in the treatment of leprosy. Progress during the first year.

Introduction of diphenylthiourea (thiambutosine) therapy.

1563 CE

#1815

Colóquios dos simples, e drogas he cousas mediçinais da Índia e assi dalgũas frutas achadas nella onde se tratam algũas cousas tocantes a medicina, pratica, e outras cousas boas pera saber.

The first account of Indian materia medica and the first textbook on tropical medicine written by a European. It includes a classic account of Asiatic cholera, the first account of this disease by a European. This is …

1656 CE

#7620

Cortex Peruviae redivivus, profligator febrium, assertus ab impugnationibus Melippi Protimi ...

The first book on Peruvian bark or cinchona (chinchona) in the treatment of malaria.

1519 CE

#9847

De guaiaci medicina et morbo gallico liber unus.

The German scholar, poet, satirist and reformer von Hutten issued a remarkably widely published and influential account of his suffering from syphilis and his treatment with gum from Guaiacum wood. This is considered …

1658 CE

#1825

De Indiae utriusque re naturali et medica libri quatuordecim.

This is an extensively revised and enlarged second edition of Piso’s Historia naturalis Brasiliae (1648). In this edition Piso reprinted Bontius's De medicina Indorum (1642) with two additional books on Asian fl…

1862 CE

#2388

Della trasmissione delle sifilide mediante la inoculazione del sangue.

Proof of the possibility of transmission of syphilis by blood transfusion.

1794 CE

#8004

Demostracion de las eficaces virtudes nuevamente descubiertas en las raices de dos plantas de Nueva-España, especies de ágave y de begónia, para la curacion del vicio venéreo y escrofuloso ...

Balmis conducted experimental trials on the effectiveness of two Mexican plants, agave and begonia, which were believed, according to folk medicine practices in Mexico, to cure syphilis and scrofula. The trials confir…

1751 CE

#1832

Descriptions, virtues, and uses of sundry plants of these northern parts of America, and particularly of the newly discovered Indian cure for the venereal disease.

Bartram founded one of the first botanical gardens in America (at Kingsessing). Linnaeus referred to him as the “greatest natural botanist in the world”. A few copies of this 7-page work printed by Benjami…

1911 CE

#5172

Die bakteriologische Blutuntersuchung beim Milzbrand des Menschen.

Salvarsan first used in the treatment of anthrax.

1910 CE

#2403

Die experimentelle Chemotherapie der Spirillosen (Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie).

After many experiments on the action of synthetic drugs upon spirochetal diseases, Ehrlich and Hata in 1909 discovered Arsphenamine (Salvarsan, "the arsenic that saves", also known as “606”), an effective …

1913 CE

#2342

Die Heliotherapie der Tuberkulose.

In 1903 Rollier introduced ultra-violet light and Alpine sunlight in the treatment of surgical tuberculosis. Heliotherapy for chronic affections was advocated as early as the 5th century CE by Caelius Aurelianus.

1861 CE

#5028

Die Hydrotherapie des Typhus.

Brand’s cold bath treatment of typhoid fever consisted of total immersion in water at 65°F. and the pouring of cold water over the neck and shoulders. The cold bath treatment of fevers was instituted by Curr…

1926 CE–1927 CE

#5256

Die Wirkung des Plasmochins auf die Vogelmalaria.

Introduction of plasmoquine (pamaquin) in the treatment of malaria.

1959 CE

#2442.3

Diethyl dithiolisophthalate in the treatment of leprosy (ETIP or “Etisul”); a progress report.

Ditophal (Etisul) in leprosy.

1912 CE

#10921

Does a human tick-borne disease exist in British Columbia?

Report on the first cases of "tick paralysis", a potentially lethal disease treatable by removing the tick. Follow-up paper by Todd: "Tick bite in British Columbia," Canad. med. Assoc. J., 2 (1912) 1118-1119. Unlike m…

1684 CE

#1311

Dr. Willis's practice of physick.

The only complete edition of Willis's works in English, translated by the poet Samuel Pordage. It contains the translations of all his works except his Affectionum quae dicuntur hystericae (1671). The collection inclu…

1799 CE

#9070

Ensaios sobre algumas enfermidades d'Angola....

Azeredo noted that the tropical fevers found in Brazil and Angola were very similar. He claimed to have achieved excellent results with his “new method” of treatment, which included the use of quinine, nux…

1546 CE

#1810.1

Epistola, rationem modumque propinandi radicis Chynae decocti…

In this work on the discovery and therapeutic use of the china root (Smilax china) in the treatment of syphilis, Vesalius described the first attempt to formulate methods of identification of an exotic drug. He also o…

1926 CE

#5289

Essai de prophylaxie des trypanosomiases par des dérivés phénylarsiniques administré

First attempt to induce prophylaxis by chemical means in trypanosomiasis. With S. Nicolau and I. Galloway.

2014 CE

#13213

Ethnobotany of tuberculosis in Laos.

1970 CE

#2442.5

Experimental and clinical studies on rifampicin in treatment of leprosy.

With J. M. H. Pearson and M. F. R. Waters.

1959 CE

#2353.2

Experiments on the antituberculous activity of alpha-ethyl-thioisonicotinamide.

Ethionamide. With F. Grumbach and D. Liberman.

1491 CE

#363

Fasciculus medicinae. Add: Petrus de Tussignano: Consilium pro peste evitanda.

A collection of short medical treatises which circulated widely in manuscript, some as early as the 13th century, and was perhaps attributed by the printers to its former owner, Johannes von Kirchheim, a professor of …

1908 CE

#5282

Further results of the experimental treatment of trypanosomiasis in rats.

Trial of antimony in the treatment of trypanosomiasis.

1770 CE

#9913

Histoire des maladies de S. Domingue. 3 vols. Title of vol. 3: Traité ou abregé des plantes usuelles de S. Dominique.

Posthmously published; vol. 1 contains a life of the author. Digital facsimile from Google Books at this link.

1648 CE

#2263.1

Historia naturalis Brasiliae.

Piso's study of the natural history of Brazil was also a pioneer work on tropical medicine, and also the largest work from the standpoint of format published by the Elzeviers. The folio includes De medicina brasiliens…

1937 CE

#5213.1

La toxi-infection gonococcique expérimentale et son traitement chimiothérapique.

Levaditi and Vaisman showed that sulfanilamide protected mice against gonococcal infection.

1948 CE

#2442.1

Leprosy treated with sulphetrone in 1943.

Clinical use of solapsone (sulphetrone).

1788 CE

#13366

Les eaux minérales et thermales de Saint-Dominique. Tome 1 (All Published).

One of the earliest medical publications printed in Haiti. Duvivier, Bibliographie générale et méthodique d'Haiti, 2, p. 206.

2005 CE

#11193

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: A double blind randomized placebo-controlled trial.

Order of authorship in the original paper: Taylor, Makunde, McGarry.... The authors treated infection by the parasitic worm Wuchereria bancrofti, cause of elephantiasis (lymphatic filariasis), by killing the Wolbachia…

1822 CE

#9071

Memoria sobre a virtude toenifuga da romeira, com observações zoologicas e zoonomicas relativas á toenea, e com huma estampa.

On the use of a root medicine to treat tapeworms, roundworms and similar parasites. The author refers to cases from Portuguese Africa, India and Brazil, and gives clinical observations based on his own case studies, s…

1854 CE

#2435

Notes on native remedies. No. 1. The chaulmoogra.

Chaulmoogra oil was first introduced into Western medicine by Mouat, having been used for many centuries previously by the Chinese

1898 CE

#2513

On an epidemic of gastro-enteritis associated with the presence of a variety of the Bacillus enteritidis (Gaertner), and with positive sero-diagnostic evidence (in vivo and in vitro).

Discovery of Salm. Aertrycke in patients suffering from food poisoning.