Facets

1947 CE

#1937

“Aerosporin”, an antibiotic produced by Bacillus aerosporus Greer.

Discovery of aerosporin (polymyxin). With A. M. Brown and G. Brownlee.

1969 CE

#5351.7

A new series of 2-aminomethyltetrahydroquinoline derivatives displaying schistosomicidal activity in rodents and primates.

Oxamniquinine.

2019 CE

#11374

A randomized, controlled trial of Ebola virus disease therapeutics.

Order of authorship in the original publication: Mulangu, Dodd, Davey.... One synthetic drug (Remdesivir, an antiviral) and 3 biologicals were used in this trial. The 3 biologicals were: REGN-EB3, a triple monoclonal …

1816 CE

#11799

A treatise on the medicinal leech; including its medical and natural history, with a description of its anatomical structure; also, remarks upon the diseases, preservation, and management of leeches.

Digital facsimile from the Hathi Trust at this link.

1986 CE

#11106

Administration of 3'-Azido-3'-Deoxythmymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.

Order of authorship in the original publication: Yarchoan, Weinhold, Lyerly. The first antiviral AIDS drug, later named "Retrovir"/ Zidovudine/AZT. (Thanks to Juan Weiss for this reference and its interpretation.)

1798 CE

#11796

An entire new treatise on leeches, wherein the nature, properties, and use of that most singular and valuable reptile, is most clearly set forth.

Digital facsimiel from WellcomeLibrary.org at this link.

1675 CE–1679 CE

#536

Anatome plantarum.

Malpighi was the founder of microscopic anatomy and a pioneer in the study of plant development. He approached the subject through the study of plant tissues. His Appendix adds to the work on chick embryology Malpighi…

1889 CE

#10786

Antibiose et symbiose.

Villemin coined the term antibiosis and advanced the term from an evolutionary viewpoint. Though he presented the concept Villemin did not apply this concept to fight disease. (Thanks to Juan Weiss for this reference.)

1966 CE

#11105

Antibiotic susceptibility testing by a standardized single disk method.

The disk diffusion test, or agar diffusion test, or Kirby–Bauer test (disc-diffusion antibiotic susceptibility test, disc-diffusion antibiotic sensitivity test, KB test), for the antibiotic sensitivity of bacter…

2008 CE

#9683

Antimicrobial drugs: Chronicle of a twentieth century medical triumph.

Concerns the history of all anti-infectives, including antibacterial, antiviral, antifungal, antiprotozoal and anthelminthic agents.

1892 CE

#5243

Azione della chinina sui parasite malarici e sui corrispondente accessi febbrili.

French translation in Arch. ital. Biol., 1892, 17, 456-71.

1905 CE–1914 CE

#2518

Bacteria in relation to plant diseases. 3 vols.

One of the most careful investigations of the bacterial diseases in plants was made by Smith, who conclusively demonstrated the existence of such diseases and proposed a scheme of classification for the bacteria conce…

2007 CE

#11478

Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118.

Order of authorship in the original publication: Corr, Li, Reidel...Hill. The authors discovered that Lactobacilli produce a bacteriocin, a peptidic toxin that inhibits the growth of similar or closely related bacteri…

1889 CE

#1932.2

Bakteriolytische Enzyme als Ursache der erworbenen Immunität und die Heilung von Infectionskrankheiten durch dieselben.

Emmerich and Löw prepared a water-soluble antibiotic substance, pyocyanase, from Pseudomonas pyocanea. It inhibited pathogenic cocci and the organisms responsible for diphtheria, plague, cholera, and typhoid.

1924 CE

#11226

Catalogue of the mycological library of Howard A. Kelly. Compiled by Louis C. C. Krieger.

The catalogue was prepared for Kelly by Louis Krieger, an eminent mycologist and botanical illustrator. Entries for this library were not numbered; however in his introduction Kelly stated that the library "herewith c…

1877 CE

#1932.1

Charbon et septicémie.

Discovery of Vibrion septique (Cl. septicum), the first pathogenic anerobe to be found. Pasteur and Joubert were probably the first to realize the practical implications of antibiosis. They noted the antagonism betwee…

1907 CE

#5281

Chemotherapeutische Trypanosomen-Studien.

The first account of induced microbial drug resistance. Ehrlich encountered induced drug resistance in microbes while researching arsenical preparations as cures for sleeping sickness and other trypanosome-caused illn…

1964 CE

#5351.6

Chemotherapy of experimental Schistosoma mansoni infections with a nitro-thiazole derivative, CIBA 32, 644-Ba.

Introduction of niridazole (Ambilhar).

1946 CE

#5261.1

Chloroquine for treatment of acute attacks of vivax malaria.

Harry Most led the development of chloroquine for use in treating American troops suffering from malaria. At the beginning of the American involvement in the war there were more American casualties from malaria than f…

1956 CE–1960 CE

#86.4

Collected papers of Paul Ehrlich. Compiled and edited by F. Himmelweit. 3 vols.

Vol. I: Histology, biochemistry, and pathology, Vol. 2: Immunology and cancer research; Vol. 3: Chemotherapy. Most texts are in German. English translations are also published when available. The set includes new Engl…

1897 CE

#2510

Contribution à l’ètude des intoxications alimentaires. Recherches sur des accidents à caractères botuliniques provoqués par du jambon.

Cl. botulinum was discovered by van Ermengem in cases of food poisoning.

1698 CE

#5181

De ipecacuanha novo Gallorum antidysenterico. Resp. C[hristophe] F[riedrich] Kneussel.

There is evidence that amoebic dysentery was known to Hippocrates. The history of treatment begins with the use of ipecacuanha, the dried root of Cephaelis ipecacuanha, a plant from Brazil. This was first mentioned as…

1794 CE

#8004

Demostracion de las eficaces virtudes nuevamente descubiertas en las raices de dos plantas de Nueva-España, especies de ágave y de begónia, para la curacion del vicio venéreo y escrofuloso ...

Balmis conducted experimental trials on the effectiveness of two Mexican plants, agave and begonia, which were believed, according to folk medicine practices in Mexico, to cure syphilis and scrofula. The trials confir…

1911 CE

#5172

Die bakteriologische Blutuntersuchung beim Milzbrand des Menschen.

Salvarsan first used in the treatment of anthrax.

1910 CE

#2403

Die experimentelle Chemotherapie der Spirillosen (Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie).

After many experiments on the action of synthetic drugs upon spirochetal diseases, Ehrlich and Hata in 1909 discovered Arsphenamine (Salvarsan, "the arsenic that saves", also known as “606”), an effective …

1861 CE

#5028

Die Hydrotherapie des Typhus.

Brand’s cold bath treatment of typhoid fever consisted of total immersion in water at 65°F. and the pouring of cold water over the neck and shoulders. The cold bath treatment of fevers was instituted by Curr…

1799 CE

#9070

Ensaios sobre algumas enfermidades d'Angola....

Azeredo noted that the tropical fevers found in Brazil and Angola were very similar. He claimed to have achieved excellent results with his “new method” of treatment, which included the use of quinine, nux…

1947 CE

#5351.3

Experimental chemotherapy of filariasis. III. Effect of 1-diethylcarbamyl-4-methyl-piperazine hydrochloride against naturally acquired filarial infections in cotton rats and dogs.

Proof of antifilarial action of diethylcarbarmazine citrate (hetrazan). With S. Kushner, H. W. Stewart, E. White, W. S. Wallace, and Y. Subbarow.

1958 CE

#4011.1

Experimental ringworm in guinea pigs: oral treatment with griseofulvin.

Use of griseofulvin in the treatment of ringworm.

1911 CE

#5189

Experiments undertaken to test the efficacy of the ipecac treatment of dysentery.

Vedder demonstrated the amoebicidal action of emetine; his work led to the general adoption of emetine in the treatment of amoebic dysentery.

2005 CE

#11481

Glycan foraging in vivo by an intestine adapted bacterial symbiont.

Order of authorship in the original publication: Sonnenberg, Xu, Leip....The authors showed that complex plant carbohydrates (glycans), which the human body cannot digest, provide food for benign bacteria in the micro…

1825 CE

#11800

Histoire naturelle et médicale des sangsues, contenant la description anatomique des organes de la sangsue officinale, avec des considérations physiologiques sur ces organes; des notions très-étendues sur la conservation domestique de ce ver, sa reproduction, ses maladies, son application, etc.

Digital facsimile from Biodiversity Heritage Library at this link.

1648 CE

#2263.1

Historia naturalis Brasiliae.

Piso's study of the natural history of Brazil was also a pioneer work on tropical medicine, and also the largest work from the standpoint of format published by the Elzeviers. The folio includes De medicina brasiliens…

1925 CE

#1911

Intravenous use of dyes.

Churchman demonstrated the selective bactericidal action of gentian violet against staphylococci. See also J. exp. Med., 1912, 16, 221-47; J. Urol., 1924, 11, 1-18.

2013 CE

#8683

Leech.

Published in the "Animal" series. Seemingly a definitive work on the natural history and medical application of leeches.

1958 CE

#12215

Les champignons hallucinogenes du Mexique. Études ethnologiques, taxinomiques, biologiques, physiologiques et chimiques.

1490 CE

#47

Liber Teisir, sive rectificatio medicationis et regiminis. Antidotarium. Translated from Arabic into Hebrew by Jacobus Hebraeus; into Latin by Paravicius. Add: Averroes: Colliget.

This is a Latin translation from a Hebrew version dating from 1280. Avenzoar, the greatest Muslim physician of the Western Caliphate, described the itch-mite, Sarcoptes scabiei, serous pericarditis, mediastinal absces…

2005 CE

#11193

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: A double blind randomized placebo-controlled trial.

Order of authorship in the original paper: Taylor, Makunde, McGarry.... The authors treated infection by the parasitic worm Wuchereria bancrofti, cause of elephantiasis (lymphatic filariasis), by killing the Wolbachia…

2019 CE

#11482

Mapping human microbiome drug metabolism by gut bacteria and their genes.

Order of authorship in the original publication: Zimmermann, Simmerman-Kogadeeva, Wegmann....The authors looked at 271 drugs and 68 different species from the main taxonomic microbiome groups. Of the 271 drugs, 176 un…

1817 CE

#1843

Mémoire sur l’émétine, et sur les trois espèces d’ipecacuanha.

Isolation of emetine. It was not until a century later that Vedder demonstrated its value in the treatment of amoebiasis. Also during 1817 Magendie and Pelletier published "Recherches chimiques et physiologiques sur l…

1812 CE–1817 CE

#2160

Mémoires de chirurgie militaire, et campagnes. (Vol. 5 entitled Relation médicale de campagnes et voyages.) 5 vols.

Larrey was the greatest military surgeon in history. Of him Napoleon said: “C’est l’homme le plus vertueux que j’ai connu”. He was present at all Napoleon’s great battles and one of…

1822 CE

#9071

Memoria sobre a virtude toenifuga da romeira, com observações zoologicas e zoonomicas relativas á toenea, e com huma estampa.

On the use of a root medicine to treat tapeworms, roundworms and similar parasites. The author refers to cases from Portuguese Africa, India and Brazil, and gives clinical observations based on his own case studies, s…

1949 CE

#11102

Mushrooms in their natural habitats.

A distinctively published work illustrated stereoscopically with color View-Master slides, and incorporating the View-Master "reels" and a View-Master viewer in a box along with the conventional bound text.

2006 CE

#11772

MykoLibri. Die Biliothek der Pilzbücher.

1729 CE

#10170

Nova plantarum genera iuxta Tournefortii methodum disposita.

Micheli provided descriptions of 1900 plants, including first published descriptions of about 1400. Among those were 900 fungi and lichens, accompanied by 73 plates. He included information on "the planting, origin an…

1809 CE

#11403

Observationes in Ordines plantarum naturales. Dissertatio prima complectens Anandrarum ordines Epiphytas, Mucedines, Gastromycos et Fungo.

Link described Polyangium, the first bacterium to be described that is still recognized today. Link also described Penicillium for the first time.

1829 CE–1832 CE

#109

Observations on the organs and mode of fecundation in Orchideae and Asclepiadeae.

Discovery, in 1831, of the cell nucleus. First issued as a separate pamphlet: Observations on the Organs and Mode of Fecundation in orchideae and asclepiadeae ... [with:] Additional remarks ... London, [privately prin…

1922 CE

#1910.1

On a remarkable bacteriolytic element found in secretions and tissues.

Lysozyme, an antimicrobial enzyme that is a component of secretions such as tears and saliva. Digital facsimile from royalsocietypublishing.org at this link

1898 CE

#2513

On an epidemic of gastro-enteritis associated with the presence of a variety of the Bacillus enteritidis (Gaertner), and with positive sero-diagnostic evidence (in vivo and in vitro).

Discovery of Salm. Aertrycke in patients suffering from food poisoning.

1929 CE

#1933

On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae.

Discovery of the growth-inhibiting action of Penicillium on certain bacteria. In 1945 Fleming shared the Nobel Prize in Physiology or Medicine with Ernst Boris Chain and Sir Howard Walter Florey "for the discovery of …