Latest Entries
Recently added and updated annotations in the corpus.
1980 CE
#14256
The identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.
See also: Novick, P., Ferro, S. and Schekman, R. "Order of events in the yeast secretory pathway," Cell, 25, 1981, 461-469. In 1979 Schekman devised a genetic selection for temperature-conditional secretion-defective …
1980 CE
#14255
Transport of vesicular stomatitis virus glycoprotein in a cell-free extract.
See also: Fries & Rothman, "Transitent activity of Golgi-like membranes as donors of vescular stomatitis viral glycoprotein in vitro," J. Cell. Biol., 90, 1981, 697-704. "Rothman's research[15] details how vesicles&md…
1983 CE
#14254
Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division.
"It was at Woods Hole around July 1982, using Arbacia sea urchin eggs as his model organism, that he discovered cyclin proteins.[12] Cyclins play a key role in regulating the cell-division cycle.[16] Hunt was observin…
1976 CE
#14253
Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.
"Beginning in 1976, Nurse identified the gene cdc2 in fission yeast (Schizosaccharomyces pombe). This gene controls the progression of the cell cycle from G1 phase to S phase and the transition from G2 phase to mitosi…
1996 CE
#14252
Toward a molecular definition of long-term memory storage.
"Abstract: The storage of long-term memory is associated with a cellular program of gene expression, altered protein synthesis, and the growth of new synaptic connections. Recent studies of a variety of memory process…
1998 CE
#14251
DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission.
"Greengard's research focused on events inside the neuron caused by neurotransmitters. Specifically, Greengard and his fellow researchers studied the behavior of second messenger cascades that transform the docking of…
1957 CE
#14250
3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as reserpine rntagonists.
Carlsson demonstrated that dopamine was a neurotransmitter in the brain and not just a precursor for norepinephrine. Digital facsimile from nature.com at this link. In 2000 Arvid Carlsson shared the Nobel Prize in Phy…
1975 CE
#14249
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. II. Reconstitution of functional rough microsomes from heterologous components.
"In 1975 Günther Blobel showed that in certain cases amino acids in a protein serve as an address label that determines where a protein is to be delivered. Amino acid sequences determine whether a protein is to b…
1977 CE
#14248
Nitric oxide activates guanylate cyclase and increases guanosine 3',5'-monophosphate levels in various tissue preparations.
Murad demonstrated that nitroglycerin and related drugs worked by releasing nitric oxide into the body, which relaxed smooth muscle by elevating intracellular cyclic GMP. With W. P. Arnold, C. K. Mittal, S. Katsuki. I…
1979 CE
#14247
Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.
With CA Gruetter, BK Barry, DB McNamara, DY Gruetter, PJ Kadowitz. In 1998 Ignarro shared the Nobel Prize in Physiology or Medicine with Robert F. Furchgott and Ferid Murad "for their discoveries concerning nitric oxi…
1980 CE
#14246
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.
In 1978 Furchgott discovered a substance in endothelial cells that relaxes blood vessels, calling it endothelium-derived relaxing factor (EDRF). By 1986, he had worked out EDRF's nature and mechanism of action, and de…
1976 CE
#14245
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.
Discovery of V(D)J recombination, the genetic mechanism which produces antibody diversity. In 1987 Tonegawa was awarded the Nobel Prize in Physiology or Medicine "for his discovery of the genetic principle for generat…
1965 CE
#14244
The stimulation of epidermal proliferation by a specific protein (EGF).
Discovery of Epidermal Growth Factor (EGF). In 1986 Cohen shared the Nobel Prize in Physiology or Medicine with Rita Levi-Montalcini "for their discoveries of growth factors."
1954 CE
#14243
In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryo.
Discovery of nerve growth factor (NGF). Order of authorship in the original publication: Levi-Montalcini, Meyer, Hamburger. In 1986 Levi-Montalcini was awarded half of the Nobel Prize in Physiology or Medicine, and St…
1959 CE
#14242
Receptive fields of single neurones in the cat's striate cortex.
Also: Hubel & Wiesel, Receptive fields, binocular interaction and functional architecture in the cat's visual cortex, J. Physiol., 160, 1962, 106-154. In 1981 Hubel and Wiesel shared half of the Nobel Prize in Physiol…
1973 CE
#14241
Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase activity in human fibroblasts by lipoproteins.
Goldstein and Brown discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develo…
1960 CE
#14240
β-Hydroxy-β-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver.
In 1964 Feodor Lynen shared the Nobel Prize in Physiology or Medicine with Konrad Bloch “for their discoveries concerning the mechanism and regulation of the cholesterol and fatty acid metabolism.” Order o…
1942 CE
#14239
On the utilization of acetic acid for cholesterol formation.
See also, Rittenberg & Bloch, "The Utilization of Acetic Acid for the Synthesis of Fatty Acids," J. Biol. Chem. 160, 1945, 417-424. Bloch, "The Biological Conversion of Cholesterol to Pregnanediol," J. Biol. Chem. 157…
1931 CE
#14238
Zur Kenntnis des Vitamins-A aus Fischtranen.
In 1930 Karrer established the correct formula for carotene (the chief precursor of vitamin A), the first demonstration of the chemical structure of a vitamin. Shortly thereafter, he was able to determine the formula …
1990 CE
#14237
Historical atlas of crystallography.
2003 CE
#14236
Trepanation: History, Discovery, Theory. Edited by Robert Arnott, Stanley Finger, and C.U.M Smith.
1892 CE–1894 CE
#14235
Atlas der pathologischen Histologie des Nervensystems. Herausgegeben von Prof. V. Babes (Bucarest), P. Blocq (Paris, Prof. Ehrlich (Berlin), Prof. Homen (Helsingfors), Prof. P. Marie (Paris, G. Marinesco (Bucarest), Prof. Mendel (Berlin) Prof. Möli (Berlin), Dozen C. v. Monakow (Zürich), Prof. Ramon j Cajal (Barcelon) und Prof. Vanlair (Lüttic). Redigirt von Professor V. Babes und P. Blocq. I. Lieferung: Die krankhaften Veränderungen der Museklnerven und deren Endigungen. II. Lieferung: Régénération des nerves. Degeneration und Entzündung der Nerven.
1891 CE
#14234
Anatomie pathologique de la moelle épinière.
1999 CE
#14233
Médecins Sans Frontières. Nobel Lecture.
In 1999 Orbinsky accepted the Nobel Peace Prize for Médecins Sans Frontières “in recognition of the organization's pioneering humanitarian work on several continents." He delivered the organization…
1970 CE
#14232
Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor.
Working with sheep preparations, the authors determined that the molecular structure of TRF (thyroid releasing hormone), is 2-pyrrolidone-5-carboxylyl-histidyl-L-proline amide. On page 324, they showed the molecular s…
1971 CE
#14231
Structure of the porcine LH-and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses.
Publication in May 1971: Working with pig preparations, the authors reinvestigated the peptide that they had previously isolated, which acted as an LH-FSH releasing hormone. They performed an Edman-dansyl degradation …
1959 CE
#14230
Association of specific overt behavior pattern with blood and cardiovascular findings: Blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease.
Abstract: "Three groups of men, selected solely according to the behavior pattern which they habitually manifested in their work, were compared with respect to their serum cholesterol levels, clotting times, presence …
1936 CE
#14229
The comparative anatomy of the nervous system of vertebrates, including man. 2 vols.
This edition and translation was so extensively reworked and expanded by Kappers, Huber and Crosby that it should be considered a new work. See No. 1247 for the original edition in German. Order of authorship as publi…
1863 CE
#14228
The principles and practice of surgery, embracing minor and oeprative surgery; with a bibliographical index of American surgical writers from the year 1783 to 1860. Illustrated by 400 wood-cuts and nearly 1000 engravings on steel. 2 vols.
The most extensively illustrated American manual of surgery issued during the U.S. Civil War.
1959 CE
#14227
Einführung in die stereotaktischen Operationen mit einem Atlas des menschlichen Gehirns. Introduction to stereotaxis with an atlas of the human brain. Large folio text plus 2 large folio binders of plates with captions.
2003 CE
#14226
Dental practice in Europe at the end of the 18th century. Edited by Christine Hilliam.
1991 CE
#14225
Brass plate and brazen impudence: Dental practice in the provinces 1755-1855.
1981 CE
#14224
The crystallization of ribsomal proteins from the 50 S subunit of the Escherichia coli and Bacillus stearothermophilus ribosome.
The authors crystallized fragments of the 50S subunit of a thermophile bacterium’s ribosome to 3 angstroms resolution. Order of authorship in the original publication: Appelt, Dyck, et al., Yonath. Digital facsi…
1954 CE
#14223
The structure of haemoglobin - IV. Sign determination by the isomorphous replacement method.
The first demonstration of isomorphous replacement in protein crystallography. This was a key step in determination of the structure of large biological molecules. Harittai, "On the origins of isomorphous replacement …
1976 CE
#14222
Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus.
The authors studied 5 diabetic patients and first realized that A1c was an ideal index to reveal the overall control of a patient’s blood sugar over the past several months before a doctor’s visit. They we…
2023 CE
#14221
The Kirtsos historical library of homoeopathic medicine: An annotated bibliographical catalogue.
The definitive bibliographical catalogue of the historical literature of homeopathy.
2012 CE
#14220
Medicinal plants of Central Asia: Uzbekistan and Kyrgystan.
"... the first English-language book detailing medicinal plant diversity in the region. More than two hundred of the most important medicinal plants of Central Asia are listed and it includes many whose medicinal uses…
1996 CE
#14219
Jean Fery: A sixteen century case of dissociative identity disorder.
Abstract: "This discussion reinterprets a sixteenth-century case of possession and exorcism ashttps://archive.org/details/lapossessiondeje00bour/page/n7/mode/2up Dissociative Identity Disorder (DID), formerly known as…
2021 CE
#14218
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
Using the base editor enzyme developed by Liu (GM11865), the authors report that they can “correct the pathogenic HGPS mutation in cultured fibroblasts derived from children with progeria and in a mouse model of…
2003 CE
#14217
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.
The authors showed that mutations in lamin A (LMNA) are the cause of Hutchinson-Gilford progeria sundrom (HGPS). At the end of their abstract they stated that "The discovery of the molecular basis of this disease may …
1970 CE
#14216
Hammond's wall atlas of human anatomy.
With pages measuring 731 x 536 mm., this is the largest anatomical atlas ever published with plastic overlays. The covers include metal grommets so that the book could be hung on the wall. The work was undated, but is…
1825 CE
#14215
Elements of operative midwifery.
Davis introduced a number of improvements in instruments and techniques: “It outlines rules and precautions for undertaking operations, described the use of various forms of forceps, and provided twenty detailed…
1859 CE
#14214
Neue Untersuchungen über den Bau des Rückenmarks. 2 vols. (Text and atlas.)
Stilling carried out some of the 19th century’s most detailed and precise examinations of the spinal cord, which “laid the foundation for the modern anatomical study of the spinal cord, medulla oblongata, …
1843 CE
#14213
Ueber die Textur und Function der Medulla oblongata. 2 vols. (Text and atlas).
“In this book, there are many transverse section figures from the origin of the 2nd cervical nerve pair up to the pons. Stilling aimed to reveal the difference between the spinal cord and medulla oblongata by pr…
1983 CE
#14212
Evidence for plasmid mediated toxin production in Bacillus anthracis.
The authors illustrated and proved that “heating V770-NPI-R containing anthrax strains, to exactly 42.5 degrees centigrade, as Pasteur and colleagues reported in GM 14211, essentially ‘cured’ these s…
1883 CE
#14211
De l'Atténuation des virus, avec la collaboration de MM. Chamberland, Roux et Thuillier. Quatrième Congrès international d'hygiène et de démographie. Séance du 5 Septembre 1882.
In his seminal 1880 paper, Sur les maladies virulentes, et en particulier sur la maladie appelée vulgairement choléra des poules, GM-2537, Pasteur developed the idea of a protective inoculation by attenu…
1784 CE
#14210
Die Deutsche [sic] Giftpflanzen, zur Verhütung der tragischen Vorfälle in den Haushaltungen, nach ihren botanischen Kennzeichen, nebst den Heilungsmitteln.
On poisonous plants in Germany, for prevention of tragic household accidents, and remedies for the poisons. Illustrated with 16 plates. Digital facsimile from Google Books at this link.
1931 CE
#14209
U. S. Plant patent 1. Climbing or trailing rose. Filed Aug. 6, 1930. Issued Aug. 18, 1931.
This was the first patent granted for a life form. In response to complaints from the nursery industry that the future of the plant breeding industry was jeopardized by the “pirating” of new plant varietie…
1991 CE
#14208
Chicxulub Crater: A possible Cretaceous/Tertiary boundary impact crater on the Yucatán Peninsula, Mexico.
Eleven years after publication of No. 14207, Alan Hildebrand, working with Luis and Walter Alvarez, proposed that the Chicxulub Crater, discovered by Antonio-Camargo-Zanoguera and Glen T. Penfield during the 1970s, wa…
1980 CE
#14207
Extraterrestrial cause for the Cretaceous-Tertiary extinction.
Following up on No. 14206, the authors stated that the same excess iridium areas were found in two different areas of W. Europe and in New Zealand, and posited that “the anomalous iridium concentrations at the C…