Facets

1884 CE

#11682

The vivisectors' directory; being a list of the licensed vivisectors in the United Kingdom; together with the leading physiologists in foreign laboratories. Compiled from authentic sources. Edited by Benjamin Bryan, with a preface by Frances Power Cobbe.

A remarkably detailed listing of scientific and medical researchers conducting research involving vivisection with address information and details of their research. This information was published in order to supply d…

1974 CE

#1588.14

The way in and the way out. François Magendie, Charles Bell and the roots of the spinal nerves. With a facsimile of Charles Bell’s annotated copy of his Idea of a new anatomy of the brain. Edited by Paul Cranefield.

An annotated bibliography of the literature documenting the history of this controversy together with reproductions of the texts of the crucial papers. See Nos. 1254-1259.

1932 CE

#664

The wisdom of the body.

A discussion of the regulation of body fluids, hunger, thirst, temperature, oxygen supply, water, sugar, and proteins of the body, and the role of the sympathetic-adrenal mechanism.

1908 CE–1952 CE

#18

The works of Aristotle translated into English. Edited by J.A. Smith and W.D. Ross. 12 vols.

De motu animalium. De incessu animalium. In his Works, edited by J.A. Smith and W.D. Ross, 5, 698a-714b., Oxford, 1912. De Anima. In his Works… translated into English. Edited by J. A. Smith and W. D. Ross. 3, …

1768 CE

#11733

The works of Robert Whytt, M.D. Late physician to his Majesty.... Published by his son.

Digital facsimile from the Internet Archive at this link.

1847 CE

#61.1

The works of William Harvey. Translated from the Latin, with a life of the author by Robert Willis.

See Sir Geoffrey Keynes’s Life of William Harvey, Oxford, 1966, (2nd printing, with corrections, 1978) and his Bibliography of the writings of William Harvey, 3rd ed., revised by Gweneth Whitteridge and Christin…

1842 CE

#11109

Theophili Protospatharii De corporis humani fabrica libri v. Edidit Gulielmus Alexander Greenhill.

Extensively annotated Greek & Latin edition of this Byzantine treatise on anatomy and physiology, edited by William Alexander Greenhill. Digital facsimile from the Internet Archive at this link.

1759 CE

#470

Theoria generationis.

Wolff observed in great detail the early processes of embryonic differentiation. He disposed of the “preformation” theory, substituting his view that the organs are formed from leaf-like (blastodermic) lay…

1708 CE

#582

Theoria medica vera.

Stahl tried to explain vital phenomena by mystical means. He was the head of the so-called Animistic School which explained disease as caused by misdirected activities on the part of the soul. A three-volume German tr…

1884 CE

#2708

Therapie der Kreislauf-Störungen.

English translation in von Ziemssen’s Handbook of general therapeutics, Vol. 7, London, 1887.

1996 CE

#14252

Toward a molecular definition of long-term memory storage.

"Abstract: The storage of long-term memory is associated with a cellular program of gene expression, altered protein synthesis, and the growth of new synaptic connections. Recent studies of a variety of memory process…

1669 CE

#761

Tractatus de corde.

Lower was the first to demonstrate the scroll-like structure of the cardiac muscle. He was one of the first to transfuse blood. Chapter III of the above work records how Lower injected dark venous blood into the insuf…

1677 CE

#579

Tractatus de ventriculo et intestinis.

Glisson introduced the idea of irritability as a specific property of all human tissue, a hypothesis which had no effect upon contemporary physiology, but which was later demonstrated experimentally by Haller (No. 587).

1734 CE–1735 CE

#1547

Tractatus quatuor anatomici de aure humana. Tractatus quintus anatomicus de aure humana. Cui accedit tractatus sextus de aure monstri humani.

Important tracts on the anatomy and physiology of the ear. Cassebohm’s studies of the embryonic ear far surpassed his predecessors, including Valsalva and Morgagni, and were not themselves surpassed until the wo…

1674 CE

#2726.2

Tractatus quinque medico-physici.

Mayow was the first to locate the seat of animal heat in the muscles; he discovered the double articulation of the ribs with the spine and came near to discovering oxygen in his suggestion that the object of breathing…

1745 CE

#308

Traité d’insectologie.

This pioneering work on experimental entomology incorporates Bonnet’s most important discovery–parthenogenetic reproduction–based on his study of aphids. Bonnet used the result of this and other disc…

1749 CE

#2733

Traité de la structure du coeur, de son action, et de ses maladies. 2 vols.

Senac’s valuable treatise on the heart added much to the knowledge of the anatomy and diseases of that organ; he mentioned the leucocytes, which he considered to belong to the chyle, and he described pericarditi…

1822 CE–1823 CE

#10070

Traité de physiologie appliquée à la pathologie. 2 vols.

Broussais was the inventor of "physiological medicine", a crucial step in the development of modern scientific medicine. (Ackerknecht, Bull. Hist. Med. 27, 320). Translated into English by John Bell and R. La Roche as…

1715 CE

#7247

Traité nouveau de la structure et des causes du mouvement naturel du coeur. IN: Oeuvres françoises de M. Vieussens dédiées a nosseigneurs des états de la province de Languedoc.

The first work on cardiac anatomy and pathology. Vieussens was the first to describe the course of the coronary arteries and the coronary sinus. He also described collateral vessels connecting the left anterior descen…

1975 CE

#14249

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. II. Reconstitution of functional rough microsomes from heterologous components.

"In 1975 Günther Blobel showed that in certain cases amino acids in a protein serve as an address label that determines where a protein is to be delivered. Amino acid sequences determine whether a protein is to b…

1975 CE

#1588.16

Translations in respiratory physiology.

English translations of 22 classic papers (some quite lengthy) with introductions by various experts.

1978 CE

#13540

Transmissible agent in non-A, non-B hepatitis.

The first paper recording the discovery of what was, eleven years later in 1989, named the hepatitis C virus (see No. 12653). Harvey Alter and colleagues inoculated the serum/plasma of 4 patients with non-A/non-B hepa…

1997 CE

#13541

Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA.

Rice and colleagues constructed a viral RNA genome with the 3’ region and a consensus region to exclude potential inactivating mutations, which was then injected into the liver of chimps. That RNA, specifically …

1971 CE

#4729.2

Transmission of two subacute spongiform encephalopathies of man (Kuru and Creutzfeldt–Jakob disease) to New World monkeys.

Following Hadlow's suggestion (1959), Gadjusek was able to transmit Kuru and Creutzfeldt–Jakob disease to primates through cerebral inoculations. Similarity in the clinical course of the diseases and in the cell…

1908 CE

#4235

Transplantation in mass of the kidneys.

Carrel revolutionized vascular surgery. He transplanted the kidney from one animal to another, an operation later carried out successfully in man. For his earlier work on vascular anastomosis and transplantation of vi…

1980 CE

#14255

Transport of vesicular stomatitis virus glycoprotein in a cell-free extract.

See also: Fries & Rothman, "Transitent activity of Golgi-like membranes as donors of vescular stomatitis viral glycoprotein in vitro," J. Cell. Biol., 90, 1981, 697-704. "Rothman's research[15] details how vesicles&md…

1944 CE

#2725

Treatment of kidney disease and hypertensive vascular disease with rice diet.

Kempner rice diet for the treatment of hypertension.

1926 CE

#3140

Treatment of pernicious anemia by a special diet.

Introduction of raw liver diet in the treatment of pernicious anemia. This treatment ranks as one of the greatest modern advances in therapy. See also the later paper in the same journal, 1927, 89,759-66. Reprinted in…

1982 CE

#14266

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

In 1982 Allison discovered the T-cell receptor. Order of authorship in the original publication: Allison, Bloch, McIntyre.

1644 CE

#11581

Two treatises in the one of which the nature of bodies, in the other, the nature of mans soule is looked into in way of discovery of the immortality of reasonable soules.

"Digby's Two Treatises was intended to prove the immortality of the rational soul and its distinction from the material body, a dualistic view shared by many of his contemporaries. the work is noteworthy on several co…

1936 CE

#1153

Über Bestandteile der Nebennieren-Rinde. VI. Trennungsmethoden sowie Isolierung der Substanzen Fa, H, und j.

Isolation of Compound Fa, identical with Compounds E and F. "In the mid-1930s Edward Kendall and Tadeus Reichstein succeeded in isolating and analyzing the composition of a number of similar hormones derived from the …

1933 CE

#1570.1

Über den Knall und die Theorie des Hörens.

In 1961 Békésy was awarded the Nobel Prize in Physiology or Medicine "for his discoveries of the physical mechanism of stimulation within the cochlea." English translation in Békésy, Experi…

1868 CE

#819.1

Über den zeitlichen Verlauf der negativen Schwankung des Nervenstroms.

Bernstein introduced the differential rheotome, and the first electrocardiograms were obtained with it by Marchand in 1877 (No. 823.1).

1886 CE

#12293

Über die Beziehung zwischen Reizung und Erregung im Tetanus.

One mechanism that has been implicated in the origin of arrhythmias is the Wedensky effect. This was first described in neuromuscular studies by Wedensky as a prolonged lowered threshold of excitability induced by a s…

1906 CE

#843.1

Über die direkte Ableitung der Aktionsströme des menschlichen Herzens vom Oesophagus und über das Elektrokardiogramm des Fötus.

Fetal electrocardiogram recorded. Cremer was also the first to record an electrocardiogram with an electrode in the esophagus.

1848 CE

#809

Über die Herznerven des Frosches.

1934 CE

#1201

Über die Synthese des Testikelhormons (Androsteron) und Stereoisomerer desselben durch Abbau hydrierter Sterine.

First complete synthesis of a sex hormone (androsterone). With M. W. Goldberg, J. Meyer, H. Brüngger, and E. Eichenberger. In 1939 Ruzicka shared the 1939 Nobel Prize in Chemistry with Butenandt (No. 1195) "for h…

1924 CE

#530

Über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren.

This was Hilde Mangold's thesis. Spemann designed the experiment, and Mangold performed the work, and was the co-discoverer of the "organizer," the chemical that directs the embryonic development of tissues and organs…

1944 CE

#1928.3

Über Konstitution und toxische Wirkung von natürlichen und neuen synthetischen insektentötenden Stoffen.

Müller introduced Dichlordiphenyltrichlorethane (DDT) as an insecticide. With H. Martin and P. Läuger. In 1948 Müller received the Nobel Prize in Physiology or Medicine "for his discovery of the high ef…

1885 CE

#4626

Ueber Aphasie.

“Lichtheim’s disease”– subcortical sensory aphasia. Lichtheim noted that although the patient could not speak, he was able to indicate with his fingers the number of syllables in the word of wh…

1918 CE

#959

Ueber das Vorkommen des Coferments des alcoholischen Hefegärung im Muskelgewebe und seine muttmassliche Bedeutung im Atmungsmechanismus.

In 1922 Meyerhof was awarded half of the Nobel Prize in Pysiology or Medicine "for his discovery of the fixed relationship between the consumption of oxygen and the metabolism of lactic acid in the muscle." The other …

1890 CE

#2544

Ueber das Zustandekommen der Diphtherie-Immunität und der Tetanus-Immunität bei Thieren.

Antitoxins and their immunizing powers were discovered when Behring and Kitasato published their paper dealing with immunity to tetanus and diphtheria. This work laid the foundation of all future treatment with antito…

1861 CE

#486

Ueber den Bau und die Entwickelung der Wirbelthier-Eier mit partieller Dottertheilung.

Proof that the ovum is unicellular in all vertebrates.

1781 CE

#104

Ueber den Bildungstrieb und das Zeugungsgeschäft.

Blumenbach, Professor of Medicine at Göttingen, was the founder of modern anthropology. In the above work he rejected the “preformation” theory and advanced the theory of epigenesis as the true explan…

1908 CE

#524

Ueber den chemischen Character des Befruchtungvorgangs.

1876 CE

#781

Ueber den Druck in den Blutcapillaren der menschlichen Haut.

Kries attempted to measure blood pressure in the capillaries by using a skin blanching method.

1837 CE

#804

Ueber den Herzstoss und die durch die Herzbewegungen verursachten Töne.

Skoda’s theory of the heart beat.

1890 CE

#1282

Ueber den Nachweis der Unermüdlichkeit des Säugethiernerven.

Bowditch demonstrated the indefatigability of nerve (“Bowditch’s law”).

1843 CE

#609

Ueber den sogennanten Froschstrom.

First description and definition of electrotonus.

1893 CE

#642

Ueber den Ursprung der Muskelkraft.