Facets

1901 CE

#5779

The treatment of cancer of the breast by öophorectomy and thyroid extract.

1916 CE

#11820

The treatment of diabetes mellitus, with observations upon the disease based upon one thousand cases.

Joslin was the first physician in the United States to specialize in the treatment of diabetes; this was the first textbook on the subject in the English language. The book underwent its 12th edition in 1985. Digital …

1906 CE–1907 CE

#4194.1

The treatment of malignant diseases of the bladder through suprapubic incision, with report of a case.

Radiotherapy for carcinoma of bladder.

1939 CE

#5172.1

The use of anthrax vaccines prepared from avirulent (uncapsulatec) variants of Bacillus anthracis.

Nonencapsulated spore vaccine.

1937 CE

#5467

The use of yellow fever virus modified by in vitro cultivation for human immunization.

Immunization without the use of immune serum. In 1951 Theiler was awared the Nobel Prize in Physiology or Medicine "for his discovery of an effective vaccine against yellow fever." This was the first Nobel Prize award…

1924 CE

#3851

The value of iodine in exophthalmic goitre.

Plummer and Boothby recommended the pre-operative administration of iodine in exophthalmic goitre.

1963 CE

#2660.16

The Vinca alkaloids: a new class of oncolytic agents.

Clinical use of vinblastine (for Hodgkin’s disease and other lymphomas) and vincristine (for acute leukemias of childhood). With J. G. Armstrong, M. Gorman, and J. P. Burnett. Preliminary communication in J. Lab…

1925 CE

#3863

Therapeutischer Versuch bei Ostitis fibrosa generalisata mittels Exstirpation eines Epithelkörperchentumors.

Mandl was the first successfully to treat generalized osteitis fibrosa by extirpation of a parathyroid tumor.

1835 CE

#4027

Thèse inaugurale sur la découverte de l’insecte qui produit la contagion de la gale, du prurigo et du phlyzacia.

Demonstration of the human itch-mite, Sarcoptes scabiei. It was due to Renucci that the Sarcoptes was recognized as the one cause of scabies and its parasitic nature finally accepted.

1653 CE

#5160

Thesis de carbunculo.

1970 CE

#7325

Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.

Classic paper on the prognosis of melanoma. Digital facsimile available from PubMedCentral at this link.

1966 CE

#2578.37

Thymus-marrow cell combinations, Synergism in antibody production.

T cell subsets. With R.F. Triplett.

1952 CE

#14100

Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium.

A cell biologist at Johns Hopkins Hospital, Gey propagated the HeLa cell line from Henrietta Lacks' cervical tumor. This cell line, which maintained a continuous growth phase, was the first immortal human cell line to…

1950 CE

#3215.1

Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma: A study of 684 proved cases.

A case-control study proving an association between heavy prolonged cigarette smoking and bronchogenic carcinoma. See also the following paper on pp. 336-38. Reprinted in J. Amer. med. Assoc. 1985, 253, 2986-97.

1965 CE

#1207.1

Total synthesis of crystalline bovine insulin.

1974 CE

#2578.42

Towards a network theory of the immune system.

Idiotype networks. Jerne shared the 1984 Nobel Prize with Milstein and Köhler for his theoretical contributions to our concept of the immune system.

1777 CE

#3983

Tractatus de morbis cutaneis.

Lorry is regarded as the founder of French dermatology. A pupil of Jean Astruc, his most important work was his Tractatus, in which he attempted the classification of diseases on the basis of essential relations, thei…

1496 CE–1497 CE

#2362

Tractatus de pestilentiali scorra sive mala de Franzos: originem remediaqu[ue] eiusdem continens.

Grünpeck was first to record mixed primary lesions, multiple primary lesions, and to note the second incubation period of syphilis. A translation of the above is in Arch. Derm. Syph. (Chicago), 1930, 22, 430. Dig…

1683 CE

#1545

Traité de l’organe de l’ouie; contenant la structure, les usages et les maladies de toutes les parties de l’oreille.

The first scientific account of the structure, function and diseases of the ear. Du Verney showed that the bony external meatus develops from the tympanic ring and that the mastoid air cells communicate with the tympa…

1759 CE

#11137

Traité de tumeurs et des ulcères, où l'on a tâché de joindre à une théorie solide, la pratique la plus sûre et la mieux éprouvée ; avec deux lettres : I. Sur la composition de remèdes dont on vante l'utilité et dont on cache la préparation : II. Sur la nature et le succès des nouveaux remèdes qu'on propose pour la guérison des maladies vénériennes. 2 vols.

The earliest French work on dermatology, and one of the earliest works in dermatopathology, including tumors of the skin. Digital facsimile of the 1768 second edition from Google Books at this link.

1852 CE

#5203

Traité des affections de la peau symptomatiques de la syphilis.

Bassereau defined chancroid clearly for the first time.

1831 CE

#9354

Traité des maladies cutanées des pieds, telles que cors, oignon, durillons, verrues, ongles, etc.

Probably the first book specifically on the skin diseases of the feet, including the functions and nature of the skin of the feet and the manner in which perspiration takes place in the feet. Nothing is known regardin…

1851 CE

#6965

Traité pratique des maladies cancéreuses et des affections curables confondues avec le cancer.

Lebert studied cancer cells under high magnification to discover the specific elements distinguishing them from normal cells. He classified tumors as either homeomorphous (composed of elements analogous to those of th…

1833 CE

#6028

Traité pratique des maladies de l’utérus et de ses annexes. 2 vols. and atlas.

Boivin and Dugès practiced amputation of the cervix for chronic ulceration. On page 648 of vol. 2 is the first recorded case of cancer of the female urethra. English translation, 1834.

1860 CE

#4048

Traité pratique des maladies de la peau. 3 éd., 2 vols.

Gibert’s name is associated with pityriasis rosea, which he first established as a definite clinical entity. His complete and accurate description of this condition is on page 402 of vol. 1 of the above work.

1826 CE–1827 CE

#3989

Traité théorique et pratique des maladies de la peau. 2 vols, and atlas.

In this summary of dermatological literature of the period Rayer first described adenoma sebaceum and xanthoma multiplex. He was the first to differentiate between acute and chronic eczema. The second edition, Paris, …

1980 CE

#13985

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.

Tony Hunter discovered that tyrosine phosphorylation is a fundamental mechanism for transmembrane-signal transduction in response to growth factor stimulation, and that disregulation of such tyrosine phosphorylation, …

1959 CE

#13334

Transfusions et greffes de moelle osseuse homologue chez des humains irradiés a haute dos accidentellement.

Order of authorship in the original publication: Mathé, Jammet, Pendic et al. Mathé performed the first bone marrow graft between unrelated donors and hosts in order to save six Yugoslavian nuclear resea…

1849 CE

#1176

Transplantation der Hoden.

Berthold showed that transplantation of a cock’s testes to another part of the body prevented atrophy of the comb, the usual sequel to castration. He was thus the first to prove the existence of an internal secr…

1890 CE

#3837

Transplantation du corps thyroïde sur l’homme.

First thyroid transplantation (for treatment of cretinism).

1973 CE

#14161

Transplantation of isolated pancreatic islets into the portal vein of diabetic rats.

Lacy and colleagues showed that transplanation of murine pancreatic islet tissue into the portal vein of diabetic rats of the same inbred strain normalized the sugar levels and urine output of the rats that received t…

1851 CE

#2614

Transplantation of malignant tumors.

First experimental transplantation of tumors.

1880 CE

#6874

Tratado clinico iconografico de dermatologia quirurgica.

The first medical text in Spanish to use photographs as illustrations. Includes 17 lithographed plates (12 chromolithographs) and 3 original photographs (2 hand-colored). Giné y Partagás was a surgeon, d…

1558 CE

#1592

Trattato de la vita sobria.

Garrison considered this “the best treatise on personal hygiene and the simple life in existence”. Cornaro was called the Apostle of Senescence. "When he was about 40, Cornaro found himself exhausted and i…

1939 CE

#3877

Treatment of adrenal insufficiency by means of subcutaneous implants of pellets of desoxycorticosterone acetate (a synthetic adrenal cortical hormone).

With L. L. Engel and H. Eisenberg. For treatment of Addison’s disease by the same method, see the same journal, pp. 339-65.

1935 CE

#3659.1

Treatment of carcinoma of the ampulla of Vater.

Pancreaticoduodenectomy for cancer of pancreas. With W. B. Parsons and C. R. Mullins.

1931 CE

#2604

Treatment of hay fever by intranasal zinc ionization.

Introduction of the method.

1943 CE

#3854

Treatment of hyperthyroidism with thiourea and thiouracil.

Astwood was the first to treat human cases of hyperthyroidism with thiourea and thiouracil.

1953 CE

#3108.5

Treatment of leukemia with triethylenethiophosphoramide (Thio-TEPA); preliminary results in experimental and clinical leukemia.

With C. Zarafonetis, N. Smith, I. Woldow and D. C. H. Sun.

1950 CE

#3788.1

Triethylene melamine in the treatment of Hodgkin’s disease and allied neoplasms

With D. A. Karnofsky, J. H. Burchenal, and L. F. Craver.

1898 CE

#2266

Tropical diseases.

Manson has been called the “father of modern tropical medicine”. He had vast experience of disease in the Tropics and himself made many valuable contributions to the knowledge of this subject. He described…

1900 CE

#3887

Tumeur du corps pituitaire sans acromégalie et avec arrêt de développement des organes génitaux.

Babinski preceded Fröhlich in describing dystrophia adiposo-genitalis.

1971 CE

#13397

Tumor angiogenesis: Therapeutic implications.

Folkman reported that solid tumors are angiogenesis-dependent. He hypothesized that there was an unknown "factor" that tumors secreted to help increase their blood supply, and that if that factor could be blocked, tum…

1982 CE

#14266

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

In 1982 Allison discovered the T-cell receptor. Order of authorship in the original publication: Allison, Bloch, McIntyre.

1931 CE

#4400

Tumors of bone.

1917 CE

#4601

Tumors of the nervus acusticus and the syndrome of the cerebello-pontile angle.

Reprinted 1963.

1931 CE

#5784

Tumours of the breast. Their pathology, symptoms, diagnosis, and treatment.

1902 CE

#4137

Two cases of a rare papular disease affecting the axillary region.

“Fox–Fordyce disease”. These writers described a papular, itchy eruption, confined to the axillae, nipples and pubes, and considered to be due to a dysfunction of the apocrine glands.

1850 CE

#3818

Two cases of absence of the thyroid body and symmetrical swellings of fat tissue at the sides of the neck, connected with defective cerebral development.

Curling, of the London Hospital, was the first accurately to note the clinical picture of cretinism, which Ord was later to name “myxedema”. Curling was also the first to suggest deficiency of the thyroid …

1644 CE

#11581

Two treatises in the one of which the nature of bodies, in the other, the nature of mans soule is looked into in way of discovery of the immortality of reasonable soules.

"Digby's Two Treatises was intended to prove the immortality of the rational soul and its distinction from the material body, a dualistic view shared by many of his contemporaries. the work is noteworthy on several co…