Facets

1979 CE

#6901

Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP.

Discovery of ubiquitin-mediated protein degradation. The paper is available at doi:10.1073/pnas.76.7.3107,PMC 383772, PMID 290989. See also Hershko, A.; Ciechanover, A.; Heller, H.; Haas, A.L.; Rose, I.A. (1980), "Pro…

1984 CE

#14265

Restoration of circadian behavioral rhythms by gene transfer in Drosophila.

"At The Rockefeller University in the early 1980s, Young and his two lab members, Ted Bargiello and Rob Jackson, further investigated the circadian period gene in Drosophila. They constructed segments of recombinant D…

2018 CE

#11382

Rhetoric, medicine, and the woman writer, 1600–1700.

"How did physicians come to dominate the medical profession? Lyn Bennett challenges the seemingly self-evident belief that scientific competence accounts for physicians' dominance. Instead, she argues that the whole e…

1970 CE

#2660.23

RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Discovery of reverse transcriptase. "In 1969, Temin and a postdoctoral fellow, Satoshi Mizutani, began searching for the enzyme that was responsible for the phenomenon of viral RNA being transferred into proviral DNA.…

1994 CE

#10090

Secret doctors: Ethnomedicine of African Americans.

"Based on an ethnographic study of the traditional medicine of African Americans in the rural southern United States, this work concentrates on the original Louisiana Territory, with its Native and African American in…

1982 CE

#13932

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena.

Discovery of ribozymes (ribonucleic acid enzymes). Cech discovered that RNA itself could cut strands of RNA, suggesting that life might have started as RNA. "In the 1970s, Cech had been studying the splicing of RNA in…

1971 CE

#6890

Specific cleavage of simian virus 40 DNA by restriction endonuclease of Hemophilus influenzae.

Nathans showed that the restriction enzyme discovered by Hamilton Smith cleaved SV40 DNA into 11 specific pieces. Nathans and his student Kathleen Danna wrote: "The availability of pieces of SV40 DNA from specific sit…

1977 CE

#11044

Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Discovery of introns simultaneously with Roberts, Chow, Broker (No. 11043). Sharp's electron microscopist, Berget, visualized the introns in the electron microscope. James D. Watson took note of the profound significa…

1994 CE

#14314

Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria.

Walker used X-ray crystallography to determine the structure of ATP synthase (ATPase or adenosine triphosphatase). In 1997 Walker shared the Nobel Prize in Chemistry with Paul Boyer and Jens C. Skou “for their e…

1965 CE

#257.2

Structure of a ribonucleic acid.

The complete sequence of an alanine transfer RNA determined – the first nucleic acid structure to be determined. With seven co-authors. In 1968 Holley shared the Nobel Prize in Physiology or Medicine with Har Go…

1960 CE

#14283

Structure of haemoglobin: A three-dimensional Fourier synthesis at 5.5-A. resolution, obtained by X-ray analysis.

Solution of the structure of hemoglobin, a protein with 10,000 atoms. This was the culmination of 30 years of research by Perutz. Order of authorship in the original paper: Perutz, Rossmann, Culis, Muirhead, Will, Nor…

2000 CE

#13952

Structure of the 30S ribosomal subunit.

Ramakrishnan and colleagues determined the complete molecular structure of the 30S subunit of the ribosome and its complexes with several antibiotics. " The Abstract: "Genetic information encoded in messenger RNA is t…

1985 CE

#11060

Structure of the protein subunit in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3 Å resolution.

Discovery of the three-dimensional structure of a protein complex found in certain photosynthetic bacteria, called the photosynthetic reaction center. This was the first elucidation of the 3D crystal structure of any …

1958 CE

#752.6

Studies on polynucleotides. I. A new and general method for the chemical synthesis of the C5'-C3' intemucleotide linkage. Synthesis of deoxyribo-dinucleotides.

In 1968 Khorana shared the Nobel Prize in Physiology or Medicine with R. W. Holley and M. W. Nirenberg "for their interpretation of the genetic code and its function in protein synthesis." H. G. Khorana, T. M. Jacob, …

2005 CE

#13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This techno…

1632 CE

#287

Thaumatographia naturalis, in decem classes distincta, in quibus admiranda 1 Coeli. 2 Elementorum. 3 Meteororum. 4 Fossilium. 5 Plantarum. 6 Avium. 7 Quadrupedum. 8 Exanguium. 9 Piscium. 10 Hominis.

A unillustrated pocket guide, issued in duodecimo format on "admiranda" or wonders of nature organized in ten categories (heaven, earth, and topics relating to meteors, fossils or minerals, plants, birds, quadrupeds, …

1928 CE

#350

The brain from ape to man: A contribution to the study of the evolution and development of the human brain by Frederick Tilney. With chapters on the reconstruction of the gray matter in the primate brain stem by Henry Alsop Riley. 2 vols.

Classic study of the evolution of the central nervous system in the higher mammals. Digital facsimile from the Internet Archive at this link.

1993 CE

#14010

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Ambros and colleagues discovered the first known microRNA (miRNA), a small single-stranded non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA sil…

1854 CE

#8383

The claims of the Negro, ethnologically considered: An address before the literary societies of Western Reserve College, at commencement, July 12, 1854.

Digital facsimile from the Hathi Trust at this link.

1985 CE

#8883

The collected essays of Sir William Osler. 3 vols. Edited by John P. McGovern and Charles G. Roland.

Vol. 1: The philosophical essays. Vol. 2: The educational essays. Vol. 3: The historical and biographical essays.

2014 CE

#7289

The complete genome sequence of a Neanderthal from the Altai Mountains.

First complete sequence of a Neanderthal genome. With more than 20 co-authors. In 2022 Pääbo was awarded the Nobel Prize in Physiology or Medicine "for his discoveries concerning the genomes of extinct homin…

1955 CE

#6928

The crystal structure of the hexacarboxylic acid derived from B12 and the molecular structure of the vitamin.

The final structure of vitamin B12. With J. Pickworth, J.H. Robertson, K.N. Trueblood, R.J. Prosen, J. G. White. In 1964 Hodgkin was awarded the Nobel Prize in Chemistry "for her determinations by X-ray techniques of …

1981 CE

#14224

The crystallization of ribsomal proteins from the 50 S subunit of the Escherichia coli and Bacillus stearothermophilus ribosome.

The authors crystallized fragments of the 50S subunit of a thermophile bacterium’s ribosome to 3 angstroms resolution. Order of authorship in the original publication: Appelt, Dyck, et al., Yonath. Digital facsi…

1871 CE

#170

The descent of man, and selection in relation to sex. 2 vols.

This is really two works. The first demolished the theory that the universe was created for humans while in the second Darwin presented a mass of evidence in support of his earlier hypothesis regarding sexual selectio…

1955 CE

#1207

The disulphide bonds of insulin.

Sanger sequenced the amino acids of insulin, the first of any protein. His work “revealed that a protein has a definite constant, genetically determined sequence—and yet a sequence with no general rule for…

1963 CE

#14305

The genetic control of tertiary protein structure studies with mode systems.

In 1972 Anfinsen shared half of the Nobel Prize in Chemistry with Stanford Moore and William H. Stein for "for his work on ribonuclease, especially concerning the connection between the amino acid sequence and biologi…

1974 CE

#9941

The genetics of CAENORHABDITIS ELEGANS.

In 2002 Brenner shared the Nobel Prize in Physiology or Medicine in Physiology or Medicine with H. Robert Horvitz and John Sulston "for their discoveries concerning genetic regulation of organ development and programm…

1980 CE

#14256

The identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.

See also: Novick, P., Ferro, S. and Schekman, R. "Order of events in the yeast secretory pathway," Cell, 25, 1981, 461-469. In 1979 Schekman devised a genetic selection for temperature-conditional secretion-defective …

1926 CE

#14025

The isolation and crystallization of the enzyme urease.

Sumner first isolated and crystallized an enzyme (urease) and proved that enzymes are proteins. One month after publication of the above paper Sumner reinforced his discovery by recrystalizing urease, publishing a fol…

1863 CE

#7442

The naturalist on the river Amazons, a record of adventures, habits of animals, sketches of Brazilian and Indian life, and aspects of nature under the equator, during eleven years of travel. 2 vols.

Digital facsimile from the Internet Archive at this link.

1957 CE

#7386

The path of carbon in photosynthesis.

Discovery of the Calvin cycle, also known as the Calvin–Benson–Bassham (CBB) cycle, or reductive pentose phosphate cycle or C3 cycle — a series of biochemical redox reactions that take place in the s…

1986 CE

#8088

The path we tread: Blacks in nursing, 1854-1984.

2006 CE

#13094

The Pauling catalogue. Ava Helen and Linus Pauling papers at Oregon State University. Edited by Christoffer Petersen and Cliff Mead. 6 vols.

Vol. 1. Timeline, correspondence, publications, manuscripts & typescripts of articles, speechs, and books. Vol. 2. Science, Research Notebooks. 1917 Linus Pauling Diary. Vol. 3. Peace, Ava Helen Pauling, travel, honor…

1677 CE

#215

The primitive organization of mankind considered and examined according to the light of nature.

In response to Isaac de la Peyrere‘s theory of polygenesis, Hale, Chief Justice of the King’s Bench, advanced his own theory that the earth was not eternal, but rather had a spontaneous “beginning,&r…

1913 CE

#6920

The reflection of x-rays by crystals.

Discovery of X-ray crystallography. The father and son team of physicists, William Henry Bragg and William Lawrence Bragg, constructed the first X-ray spectrometer using crystals as gratings, using a known wavelength …

1960 CE

#14306

The sequence of the amino acid residues in performic acid-oxidized ribonuclease.

In 1959 Moore and Stein announced the first determination of the complete amino acid sequence of an enzyme, ribonuclease. In 1972 Moore and Stein shared half of the Nobel Prize in Chemistry with Christian B. Anfinsen …

2017 CE

#12851

The smile revolution in eighteenth century Paris.

2000 CE

#13953

The structural basis of ribosome activity in peptide bond synthesis.

With Poul Nissen, Jeffrey Hansen, Nenad Ban, Peter B. Moore. Steitz shared the 2009 Nobel Prize in Chemistry with Venkatraman Ramakrishnan and Ada Yonath "for studies of the structure and function of the ribosome."

1951 CE

#6846

The structure of proteins: Two hydrogen-bonded configurations of the polypeptide chain.

Pauling, his crystallographer R. B. Corey, and African-American physicist and chemist H.R. Branson announced the α-helix, a principal structural feature of proteins. Digital facsimile from the National Academy o…

1975 CE

#14182

Three-dimensional model of purple membrane obtained by electron microscopy.

The invention of Cryogenic electron microscopy (cryo-EM). The novel technique was achieved by "by applying the method to tilted specimens, and using the principles put forward by De Rosier and Klug (GM - 13935), for t…

1975 CE

#14249

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. II. Reconstitution of functional rough microsomes from heterologous components.

"In 1975 Günther Blobel showed that in certain cases amino acids in a protein serve as an address label that determines where a protein is to be delivered. Amino acid sequences determine whether a protein is to b…

1980 CE

#14255

Transport of vesicular stomatitis virus glycoprotein in a cell-free extract.

See also: Fries & Rothman, "Transitent activity of Golgi-like membranes as donors of vescular stomatitis viral glycoprotein in vitro," J. Cell. Biol., 90, 1981, 697-704. "Rothman's research[15] details how vesicles&md…

1777 CE

#10347

Two essays. [Essay I. Of suicide]

Of suicide, "probably the most widely read and most influential philosophical treatment of suicide written in modern times," was written in 1755 and originally intended to be published as one of five essays, including…

2016 CE

#10421

Vanishing America: Species extinction racial peril, and the origins of conservation.

"Nineteenth-century citizens of European descent widely believed that Native Americans would eventually vanish from the continent. Indian society was thought to be tied to the wilderness, and the manifest destiny of U…

1528 CE

#149

Vier Bücher von menschlicher Proportion.

Written, designed, and illustrated by Dürer, this work is notable for its extraordinary series of anthropometrical woodcuts. The first two books deal with the proper proportions of the human form; the third chang…

1970 CE

#2660.22

Viral RNA-dependent DNA polymerase: RNA-dependent DNA polymerase in virions of RNA tumour viruses.

In 1970 Baltimore and Temin discovered that certain viruses that have their genes in the form of RNA can copy the RNA "backward" into DNA in infected cells. The enyzme, reverse transcriptase, enables the manufacture o…

1772 CE

#154

Von der Physiognomik.

Lavater was the last of the descriptive physiognomists. He expanded the above work into Physiognomische Fragmente zur Beförderung der Menschenkenntnis und Menschenliebe, 1775-78. This was translated into English …

1841 CE–1854 CE

#11902

Voyage au Pôle Sud et dans l'Océanie sur les corvettes l'Astrolabe et la Zélée, exécuté...pendant...1837-1840, sous le commandement de M. J. DUMONT D'URVILLE... publié... sour la direction supérieure de M. [C. H.] Jacquinot, &c. 23 vols. in 22.

In 1836 King Louis-Philippe, enthusiastic for Southern Hemisphere exploration, sponsored Dumont d'Urville's plan for a circumnavigation focusing on the South Seas. D'Urville had already distinguished himself on two Pa…

1882 CE–1883 CE

#702

Zur Chemie des Zellkerns.

Among the many important contributions of Kossel was his study of the chemistry of the cell and cell-nucleus. Kossel correctly concluded that the function of nuclein is neither to act as a storage substance nor to fur…