Facets

1865 CE

#6873

Photographs (coloured from life) of the diseases of the skin.

The first dermatologic publication illustrated with photographs.

1897 CE

#3309.1

Photographs of a case of rapid destruction of the nose and face.

Malignant granuloma of the nose first described.

1966 CE

#8399

Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity.

The antibody class labeled immunoglobulin E (IgE) discovered simultanteously by two independent groups: Ishizaka's team at the Children's Asthma Research Institute and Hospital in Denver, Colorado, and by Gunnar Johan…

1910 CE

#2600.2

Physiological studies in anaphylaxis. I. The reaction of smooth muscle of the guinea-pig sensitized with horse serum.

Schultz-Dale test for anaphylaxis. See also No. 2600.5

1929 CE

#1188

Physiology of the corpus luteum.

Discovery of the corpus luteum hormone, progesterone.

1933 CE

#7829

Pigs born without eyeballs.

Hale demonstrated that pregnant pigs fed a diet deficient in vitamin A gave birth to piglets with a variety of malformations, predominantly a lack of eyes. See also: Hale, F., 'The relation of vitamin A to anophthalmo…

1846 CE

#4039

Pilzbildung in der Pityriasis versicolor.

Eichstedt discovered Pityrosporum orbiculare, fungus of pityriasis versicolor (“Eichstedt’s disease”).

1975 CE–1978 CE

#3911.1

Pioneers in neuroendocrinology. 2 vols.,

1904 CE

#4139

Pityriasis et alopécies pelliculaires.

Classic account of the different varieties of Trichophyton.

1856 CE

#4044

Pityriasis pilaris, maladie de peau non décrite par les dermatologistes.

Devergie is remembered for his clear description of pityriasis rubra pilaris, (“Devergie’s disease”). He was the first to demonstrate the presence of a fungus in eczema marginatum.

1954 CE

#14000

Plaque formation and isolation of pure lines with poliomyelitis viruses.

Dulbecco and Vogt were the first to successfully grow the poliovirus in vitro. They were also able to plaque purify it-- an essential step for subsequent vaccine production.

1963 CE

#2578.34

Plaque formation in agar by single antibody-producing cells.

Hemolytic plaque assay for enumerating antibody-forming cells.

1933 CE

#5788

Plasma cell mastitis–a lesion simulating mammary carcinoma.

First description of plasma-cell mastitis.

1942 CE

#2578.2

Pneumococcus polysaccharide as a paralyzing agent on the mechanism of immunity in white mice.

1855 CE

#9921

Portraits of diseases of the skin.

Wilson's atlas, with 48 plates drawn and engraved by the medical artist, William Bagg, was the first English large folio atlas of dermatology in the style of similar folios issued in France by Alibert and Cazenave. Th…

1994 CE

#7066

Positional cloning of the mouse obese gene and its human homologue.

Discovery of the hormone leptin and its role in regulating body weight. Friedman and associates subsequently found that injections of the encoded protein, leptin, decrease body weight of mice by reducing food intake a…

1937 CE

#3907.1

Post-partum necrosis of the anterior pituitary.

Sheehan’s syndrome – panhypopituitarism due to pituitary necrosis following post-partum hemorrhage.

1903 CE

#7315

Practical handbook of the pathology of the skin. An introduction to the histology, pathology, and bacteriology of the skin, with special reference to technique.

The first textbook on dermatopathology in English. Digital facsimile from Internet Archive at this link.

1802 CE

#5425

Practical observations on vaccination: or inoculation for the cow pock.

Coxe did much to destroy ignorant prejudice against vaccination; he was the first in Philadelphia to practice it. Like Waterhouse, he inoculated his own child as his first case.

1892 CE

#2545.1

Practical results of bacteriological researches.

Sternberg demonstrated that the serum of an animal recovered from vaccinia possesses the property of neutralizing the activity of the causative virus. His test was readily adaptable for use in various host-systems.

1814 CE

#4021.1

Practical treatise on porrigo, or scald head, and on impetigo, the humid or running teter

This treatise on infantile eczema is the only fascicule of the second volume of Willan’s On cutaneous diseases (No.4018) that ever appeared in print. It was edited for publication after Willan's death by his ste…

1963 CE

#2660.15

Pre-therapeutic experiments with the fast neutron beam from the Medical Research Council cyclotron. A symposium.

1912 CE

#4148

Precancerous dermatosis. A study of two cases of chronic atypical epithelial proliferation.

Bowen, a Boston dermatologist, first described a precancerous dermatosis (“Bowen’s disease”), which is now considered to be a variant of an intra-epidermal basal cell epithelioma.

1909 CE

#4005

Précis de dermatologie.

1810 CE–1818 CE

#3987

Précis théorique et pratique sur les maladies de la peau. 2 vols.

1939 CE

#6231

Prediction and prevention of late pregnancy accidents in diabetes.

First report of hormone treatment. Written with R.S. Titus, E.P. Joslin, and H. Hunt.

1956 CE

#7782

Preliminary communication: Malignant disease in childhood and diagnostic irradiation in-utero.

Stewart was one of the earliest to study the effect of prenatal X-rays, later replaced by ultrasound. She found that the children of mothers who received these X-rays were almost twice as likely to develop leukemia or…

1892 CE

#4107

Première note et observations préliminaires pour servir d’introduction à l’étude des prurigos diathésiques (dermites multiformes prurigineuses chroniques exacerbantes et paroxystiques, du type du prurigo de Hebra).

“Besnier’s prurigo”.

1943 CE

#1175

Preparation and properties of pituitary adrenocorticotropic hormone.

Isolation of ACTH from swine pituitaries.

1952 CE

#2578.10

Presence d’une leuco-agglutinine dans le sérum d’un cas d’agranulocytose chronique.

Discovery of leuco-agglutinins.

1969 CE

#5440.2

Prevention of varicella by zoster immune globulin.

With A. Ross, L. H. Miller, and B. Kuo.

1955 CE

#3877.1

Primary aldosteronism, a new clinical syndrome.

Primary aldosteronism (“Conn’s syndrome”).

1912 CE

#3192

Primary malignant growths of the lungs and bronchi.

Digital facsimile from the Internet Archive at this link.

1977 CE

#7828

Problems of birth defects from Hippocrates to thalidomide and after. Edited by T.V.N. Persaud.

An anthology of classic papers edited with introductions by Persaud.

1557 CE

#534.5

Prodigiorum ac ostentorum chronicon.

This encyclopedic chronology of portentious events in human history includes many monstrous births, both human and animal. Actual cases are uncritically mingled with mythical creatures. German translation, 1557. Engli…

1945 CE

#5475.1

Production of immunity to dengue with virus modified by propagation in mice.

Successful propagation of dengue in mice and production of a vaccine.

1936 CE

#5484.2

Propagation of rabies virus in tissue culture and the successful use of culture virus as antirabic vaccine.

Webster and Clow succeeded in growing rabies virus in tissue culture.

1911 CE

#2600.3

Prophylactic inoculation against hay fever.

Noon and Freeman introduced the treatment of hay fever by means of injections of pollen extract.

1936 CE

#3975

Protamine insulin.

R. B. Kerr, C. H. Best, W. R. Campbell, and A. A. Fletcher advocated the combination of zinc with insulin to delay its absorption rate. Later this was combined with protamine to form protamine zinc insulin.

1936 CE

#3974

Protamine insulinate.

Hagedorn created NPH insulin and founded Nordisk Insulinlaboratorium, known today as Novo Nordisk. NPH insulin is one of the earliest examples of engineering drug delivery. Hagedorn became interested in modifying the …

1903 CE

#5297

Protozoa in a case of tropical ulcer (Delhi sore).

Wright found Leishmania tropica in Delhi sore. He was unaware of Borovskii’s paper (No. 5294).

1915 CE

#5430.1

Pure cultivation in vivo of vaccine virus free from bacteria.

Noguchi obtained a pure culture of vaccinia virus.

1995 CE

#11997

Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.

Andersen and colleagues found that a protein fraction obtained from M. tuberculosis was immunologically active in mice, suggesting that it was one of the proteins recognized by T cells. In this paper the authors ident…

1980 CE

#12388

Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1.

First purification and publication of a dust mite allergen in 1978 by Platts-Mills and Chapman.

1959 CE

#13526

Quantitative studies of tissue transplantation immunity. IV. Induction of tolerance in newborn mice and studies on the phenomenon of Runt Disease.

First description of what became known as Graft-versus-host disease (GvDH). This the authors initially called "graft against host (GAH)." The authors cited three conditions, later known as the Billingham criteria, whi…

1954 CE

#2578.12

Quantitative studies on tissue transplantation immunity. I. The survival times of skin homografts exchanged between members of different inbred strains of mice. II. The origin, strength and duration of actively and adoptively acquired immunity.

Experimental production of immunological tolerance by Billingham and colleagues.Paper II distinguished adoptive from passive immunization. E. M. Sparrow was a co-author of paper I.

1936 CE

#7346

Quantitative und qualitative Untersuchungen über den Sympathicusstoff*. Zugleich XIV. Mitteilung über humorale Übertragung der Herznervenwirkung Ausgeführt mit Unterstützung der -Stiftung.

In this paper Loewi proved that the cardioexcitatory neurotransmitter of the sympathetic nerves is adrenaline, or actually noradrenaline.

1906 CE

#2563

Quelques remarques sur le lait aigri.

Metchnikoff researched the effect of lactic acid produced by Lactobacilli on other non-desirable bacteria in the digestive tract. He thus expanded Döderlein's (No. 6279) concept of "normal flora" beyond the vagin…

1981 CE

#7760

Radiation and human health.

The first comprehensive book summarizing the evidence relating low-level ionizing radiation to cancer and other diseases.

1970 CE

#7783

Radiation dose effects in relation to obstetric X-rays and childhood cancers.

In this study of ten million children Stewart and Kneale showed that obstetric X-rays significantly increased the rate of childhood leukemia and cancer.