Facets

1983 CE

#11814

U.S. cancer mortality rates and trends, 1950-1979. 4 vols.

Riggan supervised this long-term project of calculating and publishing cancer mortality rates and trends for every county in the United States over several decades. The last 30 of the 40 years of the underlying data b…

1936 CE

#1153

Über Bestandteile der Nebennieren-Rinde. VI. Trennungsmethoden sowie Isolierung der Substanzen Fa, H, und j.

Isolation of Compound Fa, identical with Compounds E and F. "In the mid-1930s Edward Kendall and Tadeus Reichstein succeeded in isolating and analyzing the composition of a number of similar hormones derived from the …

1927 CE

#1186

Über das Vorkommen weiblichen Sexualhormons (Menformon) im Harn von Männern.

Discovery of the estrogenic activity of male urine. With E. Dingemanse, P. C. Hart, and S. E. de Jongh.

1912 CE

#1162

Über die Funktion der Hypophyse.

Aschner was able to keep his hypophysectomized dogs alive indefinitely. He found that they developed genital hypoplasia.

1908 CE

#5484.1

Über die Immunisierung gegen Wutkrankheit.

Fermi was the first to use chemical treatment of tissue suspensions of fixed rabies virus for the preparation of vaccine (Fermi vaccine). He introduced the use of carbolic acid for this purpose.

1956 CE

#3978.2

Über die orale Behandlung des Diabetes mellitus mit N-(4-Methyl-Benzolsulfonyl)-N’Butyl-Harnstoff (D 860).

A Symposium on tolbutamide, introduced by H. Maske.

1895 CE

#6097.1

Über die sogenannten “decidualen” Geschwülste im Anschluss an normale Geburt, Abort, Blasenmole und Extrauterinschwangerschaft.

Marchand’s theory of the histogenesis of choriocarcinoma (chorionepithelioma). He considered that such tumors derived from trophoblast and not from decidua.

1934 CE

#1201

Über die Synthese des Testikelhormons (Androsteron) und Stereoisomerer desselben durch Abbau hydrierter Sterine.

First complete synthesis of a sex hormone (androsterone). With M. W. Goldberg, J. Meyer, H. Brüngger, and E. Eichenberger. In 1939 Ruzicka shared the 1939 Nobel Prize in Chemistry with Butenandt (No. 1195) "for h…

1877 CE

#6066.1

Uber drei Fälle von primärem Carcinom im Fundus und Corpus des Uterus.

Choriocarcinoma first reported.

1928 CE

#2652.1

Über ein neues Prinzip zur Herstellung höher Spannungen.

RF-powered linear accelerator.

1884 CE

#2538

Über eine Sprosspilzkrankheit der Daphnien. Beitrag zur Lehre über den Kampf der Phagocyten gegen Krankheitserreger.

Metchnikoff originated the theory of phagocytosis. He described phagocytes in leucocytes and showed their function as scavengers. Abridged English translation in Bibel, Milestones in immunology (1988).

1935 CE

#1201.1

Über krystallinisches männliches Hormon aus Hoden (Testosteron), wirksamer als aus Harn oder aus Cholesterin bereitetes Androsteron.

Isolation of testosterone from the testis. With E. Dingemanse, J. Freud, and E. Laqueur.

1926 CE

#4151.1

Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur.

“Abrikosov’s tumor”, granular-cell myoblastoma.

1904 CE

#2558.1

Über paroxysmale Hämoglobinurie.

The first description of an auto-antibody, and of an auto-immune disease, paroxysmal cold hemoglobinuria. See A.M. Silverstein, A history of immunology, New York, Academic Press, 1989, Ch. 8, The Donanth-Landsteiner a…

1897 CE

#2550.1

Über specifische Reactionen im keimfreien Filtraten aus Cholera, Typhus und Pestbouillonculturen, erzeugt durch homologes Serum.

The precipitin reaction, employed for the qualitative identification of antigens and antibodies. English translation in Bibel, Milestones in immunology,(1988) pp. 265-68.

1885 CE

#3948

Ueber Acetonurie und Diaceturie

An important investigation concerning acetone in diabetic urine.

1902 CE

#4138

Ueber Acrodermatitis chronica atrophicans.

Taylor described the condition in 1876 (No. 4069) and Herxheimer and Hartmann named it, separating it from other atrophies which had been called by a number of different names.

1904 CE

#1147.1

Ueber Adrenalin und Alkylaminoacetobrenzcatechin.

Synthesis of adrenaline.

1820 CE

#13385

Ueber angeborne menschliche Missbildungen im Allgemeinen und Hermaphroditen insbesondere. Ein Beitrag zur Physiologie, pathologischen Anatomie, und gerichtlichen Arzneiwissenschaft.

Includes an account of the Prussian intersex man, Karl Dürrge (also known as Maria Dorothea Derrier: 1780–1835). With two hand-colored plates of hermaphroditic genitalia. Digital facsimile from Google Books…

1864 CE

#3820

Ueber Basedow’sche Krankheit.

“Graefe’s sign” – the discovery by von Graefe of the failure of the eyelid to follow the eye when it is rolled downward – diagnostic of exophthalmic goitre. Partial English translation in…

1912 CE

#3897

Ueber Beziehungen der Hypophyse zum Diabetes insipidus.

Frank was the first definitely to connect the posterior lobe of the pituitary with diabetes insipidus.

1868 CE

#4056.1

Ueber Cataracten in Verbindung mit einer eigenthümlichen Haut-de-generation.

Poikiloderma congenitale (Rothmund).

1924 CE

#5069

Ueber cutane Hautreaktion mittels Diphtherie-Toxin zum Nachweis der Diphtherie-Immunität.

The “scratch test”, a cutaneous reaction for determination of susceptibility to diphtheria.

1901 CE

#5362

Ueber das Eindringen der Ankylostomalarven in die menschliche Haut.

Looss discovered that hookworms can penetrate the skin; he himself became infected when hookworm culture accidentally spilled on his hands. English translation in Kean (No. 2268.1).

1896 CE

#6101

Ueber das Fibrosarcoma ovarii mucocellulare (carcinomatodes).

Original description of “Krukenberg’s tumor”.

1895 CE–1896 CE

#1131

Ueber das normale vorkommen von Jod im Thierkörper.

Demonstration of the presence of iodine in organic combination in the thyroid. Baumann isolated an iodine-containing compound (“Thyrojodin”). The biochemical research stimulated by this work led eventually…

1889 CE

#4100

Ueber das Ulerythema ophryogenes, eine noch nicht beschriebene Hautkrankheit.

Ulerythema ophryogenes (“Taenzer’s disease”) first described.

1852 CE

#1460

Ueber das Vorhandensein bisher unbekannter eigenghümlicher Tastkörperchen (Corpuscula tactus) in den Gefühlswärzchen dermenschlichen Haut, und über die End-Ausbreitung sensitiver Nerven.

First published account of the tactile nerve endings – “Wagner’s corpuscles”.

1884 CE

#3947

Ueber das Vorkommen von Oxybuttersäure im Harn bei Diabetes mellitus.

Discovery of ß-oxybutyric acid in diabetic urine.

1890 CE

#2544

Ueber das Zustandekommen der Diphtherie-Immunität und der Tetanus-Immunität bei Thieren.

Antitoxins and their immunizing powers were discovered when Behring and Kitasato published their paper dealing with immunity to tetanus and diphtheria. This work laid the foundation of all future treatment with antito…

1899 CE

#1145

Ueber den blutdruckerregenden Bestandtheil der Nebenniere, das Epinephrin.

1876 CE

#781

Ueber den Druck in den Blutcapillaren der menschlichen Haut.

Kries attempted to measure blood pressure in the capillaries by using a skin blanching method.

1903 CE

#2627.1

Ueber den Einfluss der Röntgenstrahlen auf epitheliale Gewebe, insbesondere auf das Carcinom.

Perthes was among the first to study the inhibitory effect of x rays on carcinoma; he was a pioneer in radiotherapy.

1838 CE

#2612

Ueber den feinern Bau und die Formen der krankhaften Geschwülste. Lief. 1.

This classic work showed that Müller realized the necessity of the cell theory for the comprehension of the nature of cancer. He recognized cells, their nuclei and nucleoli, and could distinguish various types of…

1824 CE

#6025

Ueber den Gebärmutterkrebs, dessen Entstehung und Verhütung.

Classic account of cancer of the uterus.

1895 CE

#3840

Ueber den respiratorischen Gaswechsel unter dem Einfluss der Thyreoidea sowie unter verschiedenen pathologischen Zuständen.

Magnus-Levy demonstrated the increased metabolic rate in toxic goitre, confirming the work of Müller. His experimental investigations laid the foundation for the modern conception of thyroid function. See also Z.…

1926 CE

#2651

Ueber den Stoffwechsel der Tumoren.

In his important studies of the metabolism of tumors, Warburg was first to observe that malignant tissue utilizes glucose by glycolysis, whether or not oxygen is available (aerobic glycolysis). English translation, 1930.

1887 CE

#4089

Ueber die Aetiologie und Therapie der Impetigo, des Furunkels und der Sykosis.

First description of impetigo circumpilaris infantilis (“Bockhart’s impetigo”).

1904 CE

#2560

Ueber die Antikörper des Streptokokken- und Pneumokokken-Immunserums.

Bacteriotropins named and described.

1838 CE

#540

Ueber die Ausbreitung des Epithelium im menschlichen Korper.

Henle broadened the scope of his study of epithelium (No. 539) to include the covering layers of the true body cavities.

1889 CE

#2543

Ueber die bakterientödtende Wirkung des zellenfreien Blutserums.

Following Nuttall’s work, Buchner discovered a substance in blood serum that was capable of destroying bacteria. He called the substance "alexin". He demonstrated that the bactericidal power of defibrinated bloo…

1896 CE

#1179

Ueber die Bildung des Corpus luteum bei der Maus.

1903 CE

#2591.1

Ueber die biologisch nachweisbaren Veränderungen des menschlichen Blutes nach den Seruminjektion.

Serum sickness first described.

1931 CE

#1195

Ueber die chemische Untersuchung der Sexualhormone.

The male sex hormone, androsterone, was isolated in crystalline form by Butenandt. In 1939 Butenandt received half of the Nobel Prize in Chemistry "for his work on sex hormones." The other half was awarded to Leopold …

1894 CE

#5938

Ueber die eitrige metastatische Ophthalmie, besonders ihre Aetiologie und prognostische Bedeutung.

Classic account of metastatic ophthalmia.

1838 CE

#1156

Ueber die Entstehung der Glandula pituitaria.

Important description of the pituitary.

1883 CE

#3832

Ueber die Entwickelung und den Bau des Kropfes.

Important classification of thyroid tumors; fetal adenoma is described on p. 40.

1875 CE

#3941

Ueber die Erkrankungen des Auges bei Diabetes mellitus.

A record of Leber’s important studies on the disorders of the eye in diabetes.

1874 CE

#3282

Ueber die erste durch Th. Billroth am Menschen ausgeführte Kehlkopf-Exstirpation und die Anwendung eines künstlichen Kehlkopfes.

The first complete excision of the larynx for cancer, performed by Billroth on 31 December 1873 and reported by Gussenbauer. The patient left the hospital in good state on 3 March 1874. Also published in Arch. klin. C…

1884 CE

#3833

Ueber die Exstirpation des Kropfs bei Morbus basedowii.

First thyroidectomy for exophthalmic goitre. The operation reported was performed in 1880.