1940–1949

1944 CE

#12598

Micro-methods of estimating penicillin blood serum and other bodily fluids.

Fleming was the first to measure blood levels of penicillin after intramuscular, intradermal, inravenous and continuous drip administration in order to determine the correct dosage. He described his micro-measurement …

1944 CE

#2432

Notable contributors to the knowledge of syphilis.

1944 CE

#6737

Notable names in medicine and surgery.

Biographical notes and portraits of men and women whose names are perpetuated in well-known medical eponyms. 3rd. edition 1959.

1944 CE

#2605.2

Penetration of allergens into the human skin.

Proof that allergens that produce urticarial reactions can penetrate the skin from external contact and thus produce the reaction that the authors named “contact urticaria.” With F. Herrmann and R. Baer.

1944 CE

#12599

Penicillin content of blood serum after various doses of penicillin by various routes.

In this paper Fleming and colleagues explained how to choose routes of administration of penicillin as well as dosage, and reproduced the graphs/figures that showed blood levels achieved with different doses and route…

1944 CE

#4689.1

Penicillin in the treatment of meningitis.

1944 CE

#2442

Preliminary report on diasone in the treatment of leprosy.

Muir found diasone (a sulphone) valuable in the treatment of leprosy.

1944 CE

#1935

Streptomycin, a substance exhibiting antibiotic activity against Grampositive and Gram-negative bacteria.

Introduction of streptomycin. Order of authorship: Schatz, Gregory, Waksman. In 1952 Waksman was awarded the Nobel Prize in Physiology or Medicine "for ingenious, systematic, and successful studies of the soil microbe…

1944 CE

#5014

Studies in reflexes. History, psychology, synthesis and nomenclature.

Also published in book form, Chicago, 1945.

1944 CE

#255.3

Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a deoxyribonucleic acid fraction isolated from pneumococcus type III.

Demonstration that deoxyribonucleic acid (DNA) is the basic material responsible for genetic transformation. Digital facsimile from PubMedCentral at this link. Followed by: McCarty & Avery, "Studies on the chemical na…

1944 CE

#3213.1

Studies on the etiology of primary atypical pneumonia. A filterable agent transmissible to cotton rats, hamsters, and chick embryos.

The Eaton agent, isolated from primary atypical pneumonia. With G. Meiklejohn and W. van Herick.

1944 CE

#4404.02

Surgery of the hand.

Bunnell originated hand surgery as a specialty.

1944 CE

#255.2

Tempo and mode in evolution.

Simpson's seminal contribution to the modern evolutionary synthesis integrated the facts of paleontology with those of genetics and natural selection. "Simpson argued that the microevolution of population genetics was…

1944 CE

#4255

The artificial kidney: Dialyser with great area.

The Kolff artificial kidney. With H. T. J. Berk and others. Kolff first published his discovery in a neutral country (Sweden) since in 1944 Holland was occupied by the Germans. See also No. 1976.

1944 CE

#3412.1

The ascertainment of deafness in infancy and early childhood.

Tests of hearing in children.

1944 CE

#5259.2

The development of Plasmodium gallinaceum from sporozoite to erythrocytic trophozoite.

First detailed account of the full cycle of development of the avian malaria parasite P. gallinaceum.

1944 CE

#12365

The diagnosis of rheumatic fever.

The Jones criteria (later revised in 1992 and 2015) for the diagnosis of acute rheumatic fever.

1944 CE

#11548

The foetal circulation and cardiovascular system, and the changes that they undergo at birth.

The authors describe the first direct recording of the blood flow in an intact fetus, a fetal lamb. The authors performed this experiment cooperation with Sir Joseph Bancroft and Dr. D. H. Barron.

1944 CE

#1928.2

The in vitro bacteriostatic action of some simple furan derivatives.

Nitrofuran (nitrofurazone).

1944 CE

#2349.1

The pathogenesis of tuberculosis.

Classic work on the pathogenesis of tuberculosis and its immunology and hypersensitivity.

1944 CE

#3665

The serum colloidal gold reactions as a liver function test.

1944 CE

#5398.3

The therapeutic effect of para-aminobenzic acid in louse-borne typhus fever.

With J. C. Snyder, E. S. Murray, C. J. D. Zarafonetis, and R. S. Ecke.

1944 CE

#3666

The thymol turbidity test as an indicator of liver dysfunction.

1944 CE

#3664.2

Transmission of infective hepatitis to human volunteers.

MacCallum and Bradley finally proved the nature of both serum and infective hepatitis.

1944 CE

#2725

Treatment of kidney disease and hypertensive vascular disease with rice diet.

Kempner rice diet for the treatment of hypertension.

1944 CE

#1928.3

Über Konstitution und toxische Wirkung von natürlichen und neuen synthetischen insektentötenden Stoffen.

Müller introduced Dichlordiphenyltrichlorethane (DDT) as an insecticide. With H. Martin and P. Läuger. In 1948 Müller received the Nobel Prize in Physiology or Medicine "for his discovery of the high ef…

1944 CE

#8470

Une maladie Égyptienne: l'hématurie parasitaire.

1944 CE

#2028

Untersuchungen über Dextran und sein Verhalten bei parenteraler Zufuhr.

Introduction of dextran as plasma substitute.

1944 CE

#6897

What is life? The physical aspect of the living cell.

This work about the physical basis of natural phenomena influenced the young James D. Watson and others. The book was a popularization of ideas developed by Max Delbrück in his paper with Timofeeff-Ressovsky in 1…

1944 CE–1948 CE

#2447

Indice bibliográfico de lepra, 1560-1943. 3 vols.

Supplements 1-5, 1952-62.

1944 CE–1960 CE

#11603

Medical physics. Edited by Otto Glasser. 3 vols.

This nearly 4000 page work in three unusually thick volumes, written by hundreds of authors, was an encyclopedia of medical physics for its time.

1945 CE

#6439

A history of medicine.

1945 CE

#3869

A tentative test for pheochromocytoma.

The Roth–Kvale histamine test for the diagnosis of pheochromocytoma.

1945 CE

#14284

Acetylation of sulfanilamide by liver homogenates and extracts.

Discovery of co-enzyme A and its importance for intermediary metabolism. This discovery illuminated “the process by which cells make available the energy to drive their manufacturing processes” (Judson, p.…

1945 CE

#6233

Acute inversion of the uterus.

O’Sullivan’s method of replacement by intravaginal hydraulic pressure.

1945 CE

#9177

Anatomy for artists.

By the famous American social realist artist.

1945 CE

#6476

Asclepius: A collection and interpretation of the testimonies. 2 vols.

1945 CE

#10653

Atrial septal defect: Study of hemodynamics by the technique of right heart catheterization.

The first description of the use of a cardiac catheter as a diagnostic tool, in this case a congenital heart defect. The authors worked in the laboratory of Eugene Stead, Jr. at Grady Memorial Hospital, Atlanta, Georgia.

1945 CE

#1936

Bacitracin: a new antibiotic produced by a member of the B, subtilis group.

With H. Anker and F. L. Meleney.

1945 CE

#8057

Bibliography of the technical work of the Health Organisation of the League of Nations, 1920-1945.

1945 CE

#4276.1

Bilateral adrenalectomy in prostatic cancer; clinical features and urinary excretion of 17-ketosteroids and estrogen.

Adrenalectomy for carcinoma of the prostate.

1945 CE

#1929

British anti-lewisite (BAL).

British Anti-Lewisite BAL (dimercaprol), a medication used to treat acute poisoning by arsenic, mercury, gold, and lead, was discovered during the 1939-45 war. With L. A. Stocken and R. H. S. Thompson.

1945 CE

#2061

Cinchona in Java: The story of quinine.

1945 CE

#3044

Congenital coarctation of the aorta and its surgical treatment.

Crafoord and Gross (No. 3044.1) pioneered this basic operation in cardiac and pediatric surgery.

1945 CE

#3105

Conglutination test for Rh sensitization.

Conglutination test.

1945 CE

#5399

Cultivation of Rickettsia tsutsugamushi in lungs of rodents. Preparation of a scrub-typhus vaccine.

Scrub-typhus vaccine.

1945 CE

#3103

Cyanosis in infants caused by nitrates in well water.

Methemoglobinemia. Comly first suggested the above hypothesis, since proved valid.

1945 CE

#3104

Detection of weak and “incomplete” Rh agglutinins: a new test.

Coombs’s test for detecting antibodies in various clinical scenarios, such as Rh disease and blood transfusion. With A. E. Mourant and R. R. Race. A fuller description appears in Brit. J. exp. Path.,1945, 26, 25…

1945 CE

#3701

Die Zahnheilkunde im neunzehnten Jahrhundert.

1945 CE

#1929.1

Effectiveness of a nitrofuran in the treatment of infected wounds.

First clinical use of “furacin” (nitrofuran). With C. L. Kiehn and J. W. Christopherson.